RE:RE:ONCY's GOBLET trial's pancreatic cohort exceeds expectationsBelow is further background in a 2020 paper of CD47's fibrotic reaction in sclerodoma for example:
"Scleroderma is a devastating fibrotic autoimmune disease. Current treatments are partly effective in preventing disease progression but do not remove fibrotic tissue. Here, we evaluated whether scleroderma fibroblasts take advantage of the “don’t-eat-me-signal” CD47 and whether blocking CD47 enables the body’s immune system to get rid of diseased fibroblasts."
CD47 prevents the elimination of diseased fibroblasts in scleroderma- Lerbs et al. (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455137/