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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to phase 3 licensure-enabling studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > ONCY pelareorep + CD3 bispecific antibody true-killer combo
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Comment by Noteableon Nov 03, 2022 4:26pm
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Post# 35070947

RE:RE:RE:RE:RE:ONCY pelareorep + CD3 bispecific antibody true-killer combo

RE:RE:RE:RE:RE:ONCY pelareorep + CD3 bispecific antibody true-killer comboIn June 2022 Roche presented data from its T-cell engaging bispecific antibody development programmes at European Hematooty Association (EHA) 2022 congress including their investigational medicines cevostamab and RG6234 in relapsed or refractory multiple myeloma (RRMM).

Along with the recent work in demonstrating that pelareorep + CD3 bispecific antibody is a true-killer combo, in 2020 Groeneveldt et al. presented preclinical work which demonstrated that ONCY's pelareorep preconditioned the tumor microenvironment and facilitated the convertion of CD3-bispecific antibody treatment into effective immunotherapy in immunologically "cold tumors". 
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