RE:RE:RE:RE:RE:RE:RE:CD8+ TiLs and T-cell exhaustion" Tumor-infiltrating lymphocytes (TILs): These lymphocytes primarily comprise cytotoxic (CD8+) and helper (CD4+) T cells and a smaller proportion of B and NK cells. Their functions can dynamically change throughout tumor progression and in response to anticancer therapy. The presence of lymphocytes in tumors is often associated with a better clinical outcome " - ( Luigi Ippolito, ... Paola Chiarugi, 2022)
TILs are found in stroma within tumor area and contain T cells, B cells, NK cells and macrophages. TILs are important for diagnosis and prognosis in patients with many solid tumors . TILs can be classified as intratumoral (itTIL), lymphocytes localized in tumor nests having direct cell-to-cell contact, and stromal (sTIL), present in the stroma between tumor cells
Tumor infiltrating lymphocytes (TILs) is an important biomarker in tumor immunotherapeutic treatment, which refers to lymphocytes that gathered around adjacent tissue stroma or within focal areas. For breast cancer, TNBC has a higher level of TILs, followed by HER-2 positive breast cancer, and hormone receptor positive/HER-2 negative TILs are relatively the lowest.