RE:TOINV SEE BELOW AND REPLY IF POSSIBLHi Jkj.
Within the total and sub-sample of DM with CVD and low HDL groups both relative risk reductions and absolute risk reductions were reported and both are highly statistically significant. For example at dosing day 210 the RRR within DM with CVD and low HDL was 77% with p<0.04% (as I recall) and the absolute risk reduction was about 16% points (=21% MACE in control group - 5% in the rvx-208 + Crestor group). The science posters indicated this improvement is huge and highly clinically significant. So think about the implications of this in absolute terms. Suppose there was a group of 1000 patients in the control group treated with Crestor only. Then about 160 would have had a MACE event by 6 months. Now if the test group had 1000 patients then only about 50 would have had a MACE event. So now project this out to the entire DM,CVD with low HDL population and you can see many of thousands of lives being saved and improved by rvx-208 + Crestor. NOW remember that RVX holds the patents on rvx-208 and rvx-208 + Crestor treatments.
In the combined ASSURE/SUSTAIN post hoc analysis the graph presented many time by Don, Dr Wong and others numerous times it is evident that the effect of rvx-208 on MACE reduction begings veryy quickly.
That is why RVX is continuing and why Hepalink invested $50,000,000 plus to by rights for China, Hong Kong, Taiwan and Macau. It is also why we may see more partners.
As BDAZ has posted and explained that RVX had made tremendous progress in understanding the MOA of the cascading epigenetic effects of rvx-208 and these include, very importantly, reduced inflammation.
In terms of the peer reviewed journal article I thought it was already published and they are currently involved in many presentations.
My frustrations result from Don and the ineffectiveness to get all of these positive messgaes to to the broader investment community. They communicate in scientific jargon to scientists but do not talk effectively to investors. JMHO
Hope this helps.
Cheers
Toinv :)