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Resverlogix Corp T.RVX

Alternate Symbol(s):  RVXCF

Resverlogix Corp. is a Canada-based late-stage biotechnology company. The Company is engaged in epigenetics, with a focus on developing therapies for the benefit of patients with chronic diseases. Its epigenetic therapies are designed to regulate the expression of disease-causing genes. The Company's clinical program is focused on evaluating its lead candidate apabetalone (RVX-208) for the treatment of cardiovascular disease and associated comorbidities, and post-COVID-19 conditions. RVX-208 is a small molecule that is a selective bromodomain and extra-terminal (BET) inhibitor. BET bromodomain inhibition is an epigenetic mechanism that can regulate disease-causing genes. RVX-208 is a BET inhibitor selective for the second bromodomain (BD2) within the BET proteins. It partners with EVERSANA, to support the commercialization of RVX-208 for cardiovascular disease, post-COVID-19 conditions, and pulmonary arterial hypertension in Canada and the United States.


TSX:RVX - Post by User

Bullboard Posts
Post by Jkj193741on Jul 18, 2018 8:33am
156 Views
Post# 28331615

FROM MDTBL ON IV

FROM MDTBL ON IV   

EASD Oct 3 Berlin 2018 pg.75

128 Apabetalone (RVX-208) an epigenetic modifier lowers risk of mACE 
in diabetes patients with CVD by affecting monocyte adhesion to 
endothelial cells  
N.C. Wong, L. Tsujikawa, E. Kulikowski, C. Calosing, S. Wasiak, D. Gilham, 
C. Halliday, J.O. Johansson, M. Sweeney, Canada, USA 

14:30 - 16:00 Heubner Hall 
oP 22 sweetening the endothelium 
127 High glucose exposure reduces DnA demethylation of cAmP 
response element (CRE) region in enos promoter during  
pro-angiogenic CD34+ stem cell differentiation  
M. Vinci, V. Vigorelli, J. Resta, S. Genovese, G. Pompilio, Italy  
128 Apabetalone (RVX-208) an epigenetic modifier lowers risk of mACE 
in diabetes patients with CVD by affecting monocyte adhesion to 
endothelial cells  
N.C. Wong, L. Tsujikawa, E. Kulikowski, C. Calosing, S. Wasiak, D. Gilham, 
C. Halliday, J.O. Johansson, M. Sweeney, Canada, USA  
129 Liraglutide improves vascular dysfunction via regulating  
cAmP-independent PKA-siRt1/AmPK-PgC1α pathway in perivascular 
adipose tissue in obese mice  
X. Sun, F. Han, N. Hou, China  
130 methylglyoxal driven endothelial dysfunction in hyperglycaemia 
targets protein folding, protein synthesis, glycolysis and 
gluconeogenesis pathways  
N. Rabbani, A. Ashour, Z. Irshad, J. Larkin, M. Xue, P.J. Thornalley, UK, 
Saudi Arabia  
131 increased hexokinase-2-catalysed entry of glucose into glycolysis: 
key driver of metabolic dysfunction in endothelial cells in 
hyperglycaemia  
P. Thornalley, Z. Irshad, M. Xue, A. Ashour, N. Rabbani, UK, Saudi Arabia  
132 Comparative study in various model organisms regarding the 
effect of the loss of glyoxalase 1  
B. Fuchs, J. Morgenstern, J. Tyedmers, E. Lodd, J. Kroll, D. Schuhmacher, 
M. Freichel, P. Nawroth, T. Fleming, Germany

Bullboard Posts