RE:RE:Thoughts on how this slide changed over time?I was doing a week calculation to using 28 weeks. I think one mistake that makes is that it doesn't account for the 2-4 weeks between patient enrollments that they have faced and that they stated at the quarterly conf call. So if you add in a few of these 2-4 week gaps, it's probably where we are.
I am also looking at slides 18 and 19 for the CS call. He states there are "several" patients now at the 420 level that they are "dosing now". I guess that means at least 1 more. It sounds like he's saying that if they hit some DLTs and do the 6 person final run now, it would end close to year end. If they're fine and go up one more level and then do the 6 person final run, it's likely January. So I would say either gives you a rather large dose.
I do have a question around the SAE issue. We've heard 2 things and I'm really not sure where it stands. First we heard there was a Grade 4 Neutropenia (non-febrile). From all I can find, that is still considered an SAE4 event. But Marsolais said it was Grade 4 Neutropenia but only a Grade 2 SAE. I just don't get that. Has anyone been able to get to the bottom of that? In this new presentation it seems like a Grade 4 SAE.
SPCEO - on images, best thing is to upload them to Imgur.com and they provide you the link. Copy the link and put it in these messages as a hyper link (that weird upward arrow sign above). Imgur is anonymous and deletes it after a while. Only way I've found that works.
SPCEO1 wrote: Oh well Stockhouse never seems to post an image I try to include. If any of you know the trick to allow an image to s how up, let me know. It shows up when I prepare the post but never shows up when the post is posted.
SPCEO1 wrote: The first one is from the 7/19/21 Corproate Presentation and the second from yesterday's presentation - (I am hoping Stockhouse will allow the two slides to show up in this post).
One question is how did the original estimate of 28 weeks for phase 1a get so off track? Especially when they were only dosing 5 patients to get to the level where the dosage exceeds the normal dosage of Docetaxel?