RE:RE:RE:RE:Nash Phase 3 TrialYou have been very consistent on the Nash hole .....I would like to think that this option \alternative path has been considered by the Company but they opted for a Phase 3 with an interim efficacy\futility review.....The pause \delay in the Nash program is all related to the poor cash situation .....Hard to negotiate a fair deal with a partner if they know that your cash situation is dire and Paul s bluff on going alone has not worked.....The dark self inflected cloud with the Convert has not disappared and needs to be adressed soon ....Removing that dark cloud is getting more and more urgent.....and I dont believe that it will be without pain .....
qwerty22 wrote: At this point a NASH ph3 seems like a bigger miracle to me than Oncology Good News only because there's an obvious path to the oncology data
Personally my occasional prayer is for a (smallish) multi-arm Ph2 in NASH. Where Novo Nordisk have looked into semaglutide combo'd with rGH preclinically. Decided the MOAs are compatible but rejected rGH because of safety concerns in adults and instead turn to GHRH. We end up with an Egrifta arm and a combo arm. We fill the hole in the ph2 data and get a bonus combo with an exciting drug thrown in for good measure. No material grounds to think this would happen, just my little fantasy. I think if the Pharma combos start reading out with good news then combo might seem like the best (only) game in town.
palinc2000 wrote:
I am also a Christian and I am not only for resurrections in Nash but also for miracles in Oncology......However as you know God helps those who help themselves ...That's why I keep pushing for better execution in the commercial activities.... I really like the renewed focus on Hiv related ilnesses as demonstrated by the last job posted ....
Unfortunately the organisation being built by Paul mostly from scratch has gone un noticed so far but the renewed THTX is taking shape .... Someday we will see the Light and that day is not far away...
SPCEO1 wrote: As a Christian, I am all for resurrections! Let's hope we can get one with the NASH phase III trial but it will be a bonus if it happens as far as I am concerned.