RE:RE:RE:RE:Questions An average of 8 cycles seems very high, higher than I've seen in other trials. Maybe it reflects the mix of different cancer types they were picking up.
Wino115 wrote: Yes. They used polite words to convey that, but it seems pretty clear these patients were literally at the very end having had on average 8 attempted treatments, some of which probably extended them but then failed. This really was the "last chance" Hail Mary and seemed to give some a reasonable extension and perhaps alleviated some of the pain or possible pain via metastices. We know what the one patient we've prayed for went through for 2 years. I imagine it's similar for all of them. This isn't a cure, just hopefully a much safer way to lower tumor burdens and extend life. Maybe it can shrink some lucky patients to zero burden, but not most.
palinc2000 wrote: Only 2 of the 18 patients in Phase 1a remain in the trial...Do we assume that most of the 16 did not survive long enough?
qwerty22 wrote:
Seems to me they were quite defensive over oncology. I'm wondering if they are concerned that with 18 enrolled and only one clear PR that this data will be seen negatively.
For me this update is pretty good. The only real downside is it came 6 months late. It is blown away data but they hit everything they needed to hit.
I guess they are looking forward to a sizeable data set coming out of 1b and as we have said it's likely too early for that to have materialized yet.
I thought some of the colour Christain gave on the "responders" was useful. There's certainly a suggestion that there's some resistance around those patients given that in prior treatments they quickly failed on taxols. You could surmise with the PR response patient that they "beat" docetaxel.
Overall though I get the sense they are still being very cautious and conservative. Could be a while before we hear about 1b patients. Feels like a big derisk but no fanfare about that.
StableGenius97 wrote: We out here showing cancer efficacy in cancer and we out here talking about egrifta. Not the game. Egrifta. We talking about egrifta