RE:RE:RE:RE:RE:RE:RE:Questions You have to understand SD is a veryspecific description of how their tumours are responding not how they feel. It doesn't tell you anything about their general health. They may not have been experiencing this effect as any sort of improvement in the quality of their life. While SD is something for trial sponsors it might not match the expectations of the patient.
SPCEO1 wrote: Based on what I have come to know about these trials, the human factor is a big deal. Like the person who just wanted to return to a normal life after 33 weeks on the trial. Rationally, that person would have stayed on the trial as long as possible but the effort involved and the many twists and turns this person likely had already faced can easily wipe you out both physically and emotionally.
I suspect those 16 were a combination of the drug not having any impact (non-sortilin overexpressing tumors in the trial), death, exhaustion and a few at t he 420mg dose where the side efffects were an issue.
qwerty22 wrote: "I am not sure what you think is unclear."
I was trying to give my best answer to Palinc Q about whether we assume the other 16 did not survive long enough. That seems unclear. Christian gave a number of potential reasons why people might have dropped out. Sometimes contradictory (which doesn't matter too much in this context). It's unclear why people dropped out. Probably for a mix of reasons.