Sortilin and Eyesight - side effect vs efficacyhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338683/
This study is evidence that Sortilin is associated with the eyes.
Since TH902 is designed to attach to Sortilin, it causes the side effect to the eyes.
On the other hand, this so-called side effect indirectly shows that TH902 works as expected on human, since most cancer cells have Sortilin expressed on its surface.
As such, this is the question of Risk vs Benefits. The new trial protocol amendment is to strike a balance between them.
Furthermore, as TH902 is designed as salvage therapy, its benefits would likely weight more than potential risks, given these patients' conditions.