Theratechnologies Inc T.TH

Corporate Presentation AWOL

[Spartrap]

OK, it's rant time for me finally.. I guess I'm always a bit out of schedule:

What kind of company removes its Corporate Presentation, the essential tool for gathering first insights, right before and during a financing?! It's been AWOL and replaced by a placeholder since January 8 according to a Scarlet post.

Seriously, 8 days!

Where exactly, may I ask, are new investors supposed to gather informations about their new investment? That is completely unacceptable and amateurish!

And by the way, this resonates with the out-of-fashion, unattractive website, and e-mail alerts that only arrive one timeout of 3 (!!!). I agree with many here, to say that lots of changes are urgently needed in the communication department.

[scarlet1967]

Couldn't agree more, as per CFO he knows who will be the holders of millions of new shares? How is that possible? Now will all the new shareholders who have limited knowledge of this company they need to do whatever they can to stop them from flipping their holdings for a little premium.Some say the company's website is not important which is absolutely incorrect imo, They have been

[scarlet1967]

This was posted here earlier, they put it on their Twitter account today with only few thousand followers, they need to use a well known platform so they can get decent exposure. https://www.linkedin.com/posts/theratechnologies-inc_capsules-entrepreneuriales-theratechnologies-activity-6755876418296659968-XVra

[scarlet1967]

It was posted both on LinkedIn and Twitter, the Twitter account has only 90 followers?

[SPCEO1]

Was the twitter version in English?

[MHemorrhage]

No english version - just the subtitles. That are illegible on half the slides' white background. Video was done by Montreal Invivo who appears to exclusively work in French.

[scarlet1967]

On both platforms English and French.

[scarlet1967]

Yes the content was subtitled but the introduction was both in English and French.

[qwerty22]

You happy with the cancer protocol?

[Spartrap]

Yes, quite happy! It looks very straightforward, very well though out to me. If I had any reservations, that would be about the grouping of Gynecological cancers in a single basket.. Ovarian, endothelial and endometrial.. do they share enough similarities? That looks a bit odd to me intuitively, but maybe it's the case. Also, something I struggle to perfectly understand is the starting

[qwerty22]

The CRO https://www.ppd.com/therapeutic-expertise/oncology-and-hematology/

[qwerty22]

our PI wrote a book on ADCs and clinical trials https://ascopubs.org/doi/10.1200/EDBK_280775?url_ver=Z39.88-2003@rfr_id=ori:rid:crossref.org@rfr_dat=cr_pub%20%200pubmed The whole thing is super relevant and I think readable as long as you can get past the ADC as opposed to PDC factor (JFM).

[qwerty22]

FWIW I went chasing this issue. I found an abstract that helps with the mol weight issue. https://cancerres.aacrjournals.org/content/80/16_Supplement/2910.short It says "TH1902 at 8.75 mg/kg/week (equivalent to docetaxel dose of 3.75 mg/kg/week)" So my calculation starting dose at 30mg= docetaxel 12.9mg dose. You were pretty close. I also found the Simon 1997 ref, what it says

[Spartrap]

Thank you for digging out all those details, that's very helpful. So it appears we are in the right ballpark.. also, I just heard in the presentation that the dose doubling phase is indeed for the first 2 doses after the first (so: 30, 60, 120). That is just great! Also, reading your linked article about Taxotere Ph1, I noticed the following in the dicussion section: "As a matter of

[qwerty22]

You'd have to have a pretty liberal definition of "tolerate" for that to make sense. I guess because it's reversible they might mean initially tolerable but not for long. I was just about to add a little to this side conversation also, but you said it all, I'll add my bit anyway. So with 540 being top dose of Th-1902 that's equivalent of 232 docetaxel. That's

[juniper88]

My wife has had 9 cycles of Carboplatin and Taxol. The taxol dosage was 175mg/m2, which is standard. As for side effects, her neurophils went down but never so low as to postpone treatment, very slight neuropathy which dissappear by taking B6, and unfortunately all her hair fell out.