Theratechnologies Inc T.TH

Great presentation in Oncology

[palinc2000]

Paul s best delivery so far

[Wino115]

Need to look at that slide again but appears they are now up to that 2x normal dosage level (420) after the SAE 2 and need to get 3 patients at that level with no DLT to move to the next one that is 30% more drug.  It seems they've gotten there with minimal patients (9) which while that sounds slow, actually means they've been able to move up each level with just one patient because

[Wino115]

No free docetaxol - seeing the same in humans as we say in preclinical.  There's that very clear statement. 

[canadapiet]

It should also be a great indication that those very serious ill patients are still on the trial, indicating that there must be some "life extending medication" ..........isn't it????? Hope Wino115 - (11/11/2021 10:15:53 AM)  RE:RE:Great presentation in Oncology No free docetaxol - seeing the same in humans as we say in preclinical.  There's that very clear

[palinc2000]

I think Recruted  patients must have a life expectancy of at least 3 mos ...So I dont think this is a foregone conclusion,Not must but maybe could

[palinc2000]

This is what I heard also!!! It is now a Fact!!!!

[Wino115]

Yes, but only that fact surrounding them not seeing the drug accumulating in the patients blood plasma.  So it seems to indicate off-target drug release is very low (1 fact we need to account for now) and that the PDC is not degrading in the bloodstream so is going somewhere to release that drug (2nd fact we need to account for now).  My unscientific mind says this may not preclude one

[jfm1330]

Not listened to the presentation yet, but what you say below is impossible. Docetaxel is eliminated through the liver, by-products goes in the bile, and finally in the feces. Very little goes in the urine.

[SPCEO1]

When I saw that slide, it did not seem to indicate whether it was from pre-clinical or from the phase 1a. I figured it was pre-clinical but thought I should ask to be sure and I am sure glad I did! But why wouldn't that info be something they would be anxcious to share with us??? I should not have had to ask about it. What is the point is holding back such info? And what else could they share