Theratechnologies Inc T.TH

Thera on twitter with the KEY...

[TH1902]

https://twitter.com/Theratech_/status/1575188642175369216?s=20&t=QS8afHeKpFBSgstkF5qaLw

[longterm56]

Interesting. At first I thought this quote was an "overstatement" by an enthisiastic CEO in front of the public, but if that was the case they would not have continued to publicize it, would they?     -LT

[qwerty22]

I guess you could say this is based on preclinical and Ph1a but with 1b running if they aren't sitting on something that is either a solid, decent responder number or looks odds on to convert into that in the near future then I don't know what...... Given he hasn't shut up. It's time to put up Paul!

[palinc2000]

The statement by itself means absolutely nothing because it is missing the following '´and we are in the midst of conducting a Phase 1 b Clinical Trial in humans to prove that Concept" However personnally  I would not have posted that statement unless I had seen some results in humans resembling some of the  spectacular results in the pre clinical study .That would be

[PWIB123]

Nah, I don't think so.  Maybe, but in the context of how THTX has communicated in the past and the point in time with which the statement is being made, it's highly unlikely.  I think they want the investment community to know they have something, but aren't quite ready to articulate exactly how it is the key.  

[Wino115]

Recalling some of the original discussion around what kind of therapy they were hoping for, a lot revolved around the idea that their PDC internalized really quickly into the tumor cell via SORT1 and, because of that, it fooled MDC-1 reflux resistance, so got to work killing the cell where other drugs didn't.  So  1) rapid internalization & 2) gets by resistance.  That is a

[palinc2000]

Only my friend Donald Trump has the power of "thinking" about something and its done like he did when he declassified top secret documents. Unfortunately Paul does not posess that God given power and we will have to be a little more patient to find out if they find the key

[Bucknelly21]

Paul is gods gift to thera...

[Bucknelly21]

Ready for the sell off? When these zip head traders realize that they were wrong about whatever it is they thought would happen. Meanwhile the brilliant marketing team at thtx didnt take advantage of having some fresh eyes on the company. 

[qwerty22]

So presumably the FDA meet today. Then they contact TH or Taimed? I forget who is the lead on this. Then TH/Taimed release the news when? And it falls flat unless the zip heads go crazy??? BTW is there any chance Mr hairdo isn't behind this and say rumours of responders are driving the increased volume and are the evidence of the "key"?  

[Wino115]

I get it, but let's work from the premise that Paul knows a whole lot more than we do and he's likely far more adept at connecting some of the disparate datapoints coming out of the trial with the help of Marsolais, Belivieu, Rothemberg, Cancer Advisory Panel. We don't know, but he knows what the 24/48 hr plasma readings showed, what the pace of efficacy vs SAEs was at each reading

[qwerty22]

You could argue that just because the trial is still ongoing is proof enough they "think" they have the "key". If they didn't think they had the key the trials would stop. This is the problem with these statements you can go around in circles convincing yourself they do or don't have special meaning. Maybe they are less about what Paul thinks and just there to get other

[palinc2000]

I think we are thinking the same!!! As I wrote I would not have written the statement about the key if I did not have fairly strong evidence of efficacy but I think we should all be prudent in interpreting what was said....Placing over reliance on the statement is  setting up for disappointment ,,....While we dont know much about the trial we should expect only  a minority of patients in

[palinc2000]

First come first served cannot be adapted to mean First Come First Cured is what I am saying  

[jfm1330]

The key to bypass the cellular menmbrane efflux pump is the way sortilin is internalized. That is through endosomes that protect the PDC since it is not free, it is still integrated in the endosome's membrane. Then, this endosome can fuse with other endosomes or with membranes of the Golgi apparatus or endoplasmic reticulum. Ultimately the PDC will be released and cleaved, generating free