Ceapro Inc V.CZO

RE:PGX-YBG/Avenanthramide

[prophetoffactz]

Food Chem

 

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. 2024 Aug 1:448:139062.

 doi: 10.1016/j.foodchem.2024.139062. Epub 2024 Mar 20.

Yeast cell wall capsules for delivery of oat biomarker avenanthramide-C

Linyang He 1, Yubo Zhu 1, Xinghui Shen 1, Gang Chen 2, Hang Xiao 3, Jing Wang 4, Chen Tan 5

Affiliations expand

• PMID: 38531297
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• DOI: 10.1016/j.foodchem.2024.139062

Abstract

Avenanthramide-C (AVN-C) is the biomarker for oat with a variety of physiological functions, whereas its application is constrained by low stability and bioavailability. Avenanthramide-C is the biomarker for oat with a variety of physiological functions, whereas its application is constrained by low stability and bioavailability. This study evaluated the potential of yeast cell (YC) and yeast cell wall (YCW) capsules as delivery systems for stabilizing AVN-C. It was observed that these yeast capsules possessed the ellipsoidal morphology and intact structure without visual pores. Additionally, the YCW capsules exhibited higher encapsulation and loading capacity due to the large internal space. The interaction of yeast capsules with AVN-C involved the hydrophobic interactions and hydrogen bonding. Moreover, the loading of AVN-C induced high hydrophobicity inside the yeast capsules, which helped to protect AVN-C against degradation and release AVN-C in a slow and sustained manner in the simulated gastrointestinal tract. The YCW capsules have potential as controlled delivery system for AVN-C, which could be further used as a nutraceutical and added to functional foods.

prophetoffactz wrote: With the avenanthramide pill having potentially cleared 480mg at the single dose per day level now and CZO only appearing to need a 240mg twice per day level will we ultimately see a PGX-YBG/Avenanthramdie pill?

I asked Copilot what the potential health benefits are of combining avenanthramide and yeast beta glucan for treating inflammatory diseases. This is the response:

Combining avenanthramide with yeast beta glucan in the treatment of inflammatory diseases offers several potential scientific benefits:

1. Synergistic Anti-Inflammatory Action:

   • Avenanthramide: Derived from oats, avenanthramide has demonstrated anti-inflammatory properties. It inhibits the production of pro-inflammatory molecules and modulates immune responses.
   • Yeast Beta Glucan: Yeast beta glucan is known for its immunomodulatory effects. It enhances immune function, reduces inflammation, and promotes tissue repair.
   • Benefit: Together, they may have a synergistic effect, amplifying their anti-inflammatory actions. This dual approach could lead to better disease management.

2. Enhanced Bioavailability:

   • Avenanthramide: Bioavailability (how much of a substance reaches the bloodstream) is crucial for therapeutic efficacy.
   • Yeast Beta Glucan: As a carrier, yeast beta glucan can improve avenanthramide’s solubility and absorption.
   • Benefit: Enhanced bioavailability ensures that avenanthramide reaches its target tissues effectively.

3. Gut Health and Immune Modulation:

   • Avenanthramide: The gut plays a key role in inflammation. Avenanthramide may positively influence gut microbiota.
   • Yeast Beta Glucan: It interacts with gut immune cells, promoting a balanced immune response.
   • Benefit: Combining them could enhance gut health and overall immune function.

4. Cardiovascular Protection:

   • Avenanthramide: Cardiovascular diseases often involve inflammation. Avenanthramide may protect against endothelial dysfunction and atherosclerosis.
   • Yeast Beta Glucan: It has cardiovascular benefits, including cholesterol reduction.
   • Benefit: Their combined effects may mitigate cardiovascular risk factors.

5. Wound Healing and Tissue Repair:

   • Avenanthramide: It promotes tissue repair and wound healing.
   • Yeast Beta Glucan: Known for wound-healing properties.
   • Benefit: Together, they could accelerate tissue regeneration.

6. Immunomodulation without Overstimulation:

   • Avenanthramide: Balances immune responses.
   • Yeast Beta Glucan: Enhances immune function without excessive activation.
   • Benefit: Avenanthramide and yeast beta glucan may modulate immunity effectively without causing hyperinflammation.

In summary, this combination holds promise for managing inflammatory diseases by addressing multiple pathways and optimizing therapeutic outcomes.