RE:Skin-Whitening IndustryKanebo's skin whitener, Rhododenol, is only slightly different than raspberry ketone, which has been known to cause blothes by killing off melanocytes (pigment cells). Although the problem is probably related to extreme overuse, it shows how important it is to cover all the bases in safety testing. The trials leading to the approval of Rhododenol did not show blotches because they were conducted at reasonable dosages.