That's why there are so bullish...
First poster,
4601 is basically shutting down Ras-MAPK pathway. This increases efficacy by a lot.
Second poster, 4601 stop prolefiration, inhibits growth at near 100% but doesn't always show tumor regression.
However, if one combines it with a apoptosis agent. Kaboom!
https://en.wikipedia.org/wiki/Gefitinib
(note: 10% efficacy rate. Temozolomide less than 20% all patients for a mere 2.5 month life extension eventually dies)
See how lucrative these ineffective drugs are. Increasing just by 5% efficacy for an established drug could generate 1B of sales.
Bah! Deal time!
Here is the list of buyers/partners
https://en.wikipedia.org/wiki/Protein_kinase_inhibitor
Third poster, 232 kills cancer cell by starving em and induces em to commit suicide.
Amazing!
Probably more unreleased data. Such as Rho inhibition. Such as AKT inhibition for 4601.