Raf-1 inhibition and RAS-GTP level
https://en.wikipedia.org/wiki/C-Raf
check out image
https://en.wikipedia.org/wiki/File:RAF.png
We are now closer than ever to finally reveilling 4601 mecanism of action - "RAS-GTP decrease". That finding would be a major breakthrough in cancer research.
4601 is basically bypassing every mutation known to block efficacy for other drugs.
https://www.thallion.com/docs/publications/26.AACR09-Batist-Web.pdf
These posters won't ring a bell for the common market player but for oncologist, this is certainly very interesting to note:
TLN-4601 potentiates both erlotinib and gefitinib in non-small cell
lung cancer cell lines harboring sensitive or resistant TKI EGFr
mutations
TNL-4601 in combination with TKIs overcomes the T790M-TKI
Exponentially growing cells were seeded in 96-well plates at a resistant mutation (NCI-H1975)
TLN-4601 enhances erlotinib and gefitinib activity irregardless of
EGFr expression or mutation status
TLN-4601 demonstrates strong synergistic activity with erlotinib,
and to a lesser extent with gefitinib, in K-Ras mutated cells
Very nice scientific finding.
It's time to negociate how much u want to pay for TLN!
I say 4$ per share and there will be no shareholder revolt.
Cheap price tag at 120 Millions, very cheap.
(or) 200 millions licensing deal with upfront payment of 10M.
(or) white knight intervention and pumping of 30M cash infusion. Yup that's all 30M and TLN could go it alone and get accelerated market approval.