GBM, Metastatic Skin Cancer, Pancreatic
Right now 4601 is tested on GBM,
Avastin pretty much cleared the regulatory pathway, FDA will approve anything...
Exelixis remarkable results (XL184) is now less remarkable very less, but still they are fast tracking approval with a sample group of 46 patients (now planning 100)
XL-184 probably skrings edema like Avastin, response rate only 15%...
232 is currenlty testing on Metastatic skin cancer
No toxicity found and drug regime bump up to maz.
Pancreatic cancer
Warburg effect is generatin attention
https://www.sciencemag.org/cgi/content/abstract/324/5930/1029
It's in the nature magazine now.
232 is the only compound exploiting warburg.
Also, reveal before ASCO that pancreatic cancer does not oxygen or blood to survive...
I think the next trial opening for Thallion is a combo 232 + 4601 for pancreatic cancer.