RE:Oncologic Photodynamic Therapy The mean survival for patients that had FGR followed by PDT was 9 months, compared to 3.5 months of the control group, which was a significant improvement.
-That was with FOSCAN ...TLD 1433 or another TLT compound should do better
Anti-tumor immunity was first discovered when lymph node cells from PDT treated mice were transplanted to naive hosts and induced suppression of subsequent tumor challenges. PDT-treated mice proved resistant against new tumor challenge after being tumor free for 100 days after PDT, indicating that an immune memory was established [76]. The importance of the lymphoid cells in long-term PDT efficacy was confirmed when all tumors were responsive to PDT and regressed in both immunocompetent and immunodeficient mice, but only regrew in the immunedeficient mice. Transfer of immunocompetent T-cells or bone marrow to immunodeficient mice resulted in restored long-term tumor sensitivity to PDT and delayed tumor recurrence [77]. Even though the adaptive immune reaction is not essentially important in the initial tumor damage, it primes the host for recurrences of similar tumors by formation of tumor-specific memory cells [78]. The acute inflammatory response following PDT, resulting in the phagocytosis of apoptotic and necrotic tumor cells, forms the basis for this mechanism.
- This seems to confirm the immune response
This review is a good catch from Bencro . Pretty intense reading and over my head for the most part but my conclusion is this science of PDT stands a serious chance of becoming a go to therapy for a few indications .
Happy sunday