"The share price is where it should be, if that. " I disagree with this statement by PatMac , when i don't believe in a stock in my portfolio i sell it . There is a difference bettween disbelief and a few disapointments . When you do an ongoing DD you have to accept that the world is not perfect . The risk/reward scenario with TLT is what i like to call a potential home run . It would take only one special NR and this stock could be derisked instantly ( ex: the mention of involvement by a big pharma ) . LongHolder is right some people will end up with what i like to call a flat forehead ( somebody slapping the front of their head after seeing TLT go up by $$$$ )....the i should've syndrom .