RE:RE:RE:RE:RE:RE:200,000 Warrants ConvertedSkier59 ... BionicBlowJob should have done his homework better before posting:
Keytruda is required to enroll 363 patients in a Ph.1 that tests an (another) immune inhibitor checkpoint as
a single agent or in combination with Keytruda. So lets assume 180 for each of the sub-cohorts. They also need to test many doses, given that these immuno-therapy drugs are so impredictable! Immuno-therapy drugs also take weeks to months before showing signs of "efficacy" (usually shrinkages).
Our Ph. 1b NMIBC trial (that involved a solid tumor type of cancer) was authorized to enroll only 9 patients because regulatory bodies (HC, FDA) know that PDT/PDC delivers instant reactions. And our results were so impressive that the trial was ended earlier. And the last 2 patients are still cancer free @12-month, were destruction happened right after the treatment because of the ROS inside the cancer cells.
Bashers with their weak arguments always allow us to document things properly and put things into perspectives. Their posts are so amateure, so weak, that it's impossible to be scary!
A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab (Keytruda) in Subjects With Advanced Solid Tumors
Go to
| Study Type : | Interventional (Clinical Trial) |
| Estimated Enrollment : | 363 participants |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Treatment |
| Official Title: | A Phase 1b Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors |
| Actual Study Start Date : | September 8, 2017 |
| Estimated Primary Completion Date : | July 2021 |
| Estimated Study Completion Date : | April 2022 |
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Claridge - (6/15/2019 12:28:52 PM) RE:RE:RE:RE:RE:200,000 Warrants Converted For a guy that used to bash many posts/day, every single day under different aliases, you'd think he would come more prepared!
Strange (and funny at the sametime) that our clown BionicJoke:
- is silencing our higher efficacy ratios,
- is silencing our last 2 cancer free patients @12 month in one 1-hour treatment,
- is silencing the technology that allows them to see "live" whether or not cancer cells are all destroyed (Dr. Rueck's technology behind that optimized procedure),
- is silencing that we're still authorized by HC (and soon FDA) to enroll less patients, compared to immuno-therapy drugs trials, - is silencing the fact that we will not be required to do costly and time consuming Ph. 3! Thought the clown was too old to post on SH, as per his own saying!
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bionicjoe - (6/15/2019 12:13:21 PM) RE:RE:RE:RE:200,000 Warrants Converted
Thank goodness you had a few minutes to do your own DD skier59. What got into you? The reason they haven't diluted shareholders even more is because their expenses for doing animal trials and a small phase 1b human clinical trial were relatively modest. Let's see if that holds up as they ramp up for a 100 patient phase 2 trial in multiple countries. skier59 wrote:OK I had a few minutes to get the info;
As of April 1st we had a total of:
144,132,042 shares in the market.
30 cent warrants 3,159,000 with less than 1 year remaining.
37 cent warrants 7,198,599 with 2 1/2 years remaining.
the interesting ones are those 54 cent warrants, 19 million, which have about 7 months remaining.
I can guarantee you that Frosty will never let those warrants expire. Now we know why he demanded the 5 year term on them.
I'm still amazed Roger has managed to keep dilution at such a low level after all these years. I think we can also thank our great Canadian system which has certainly helped. This would never of happened if we were a USA based company. Lots of great medical things have been invented in Canada, since our invention of Basketball :)