RE:RE:RE:9 months data pointenriquesuave wrote: I agree Eoganacht, Radachlorin had 90% CR at 12 months and over 60% at 24 months with 2-3 treatments and those results were similar for both HG T1 papillary and CIS. That's why I believe we can achieve between 60-90% CR at 12 months and be a safer and instilled drug versus IV. Like I said before we were even lucky to get 25% CR given that the patient who got the best treatment was still undertreated by 39% and the one who got the worst was undertreated by 154% for an average under treatment of 75%. 25% power gave 25% CR. Let's use 110% power and get 110% CR. please. For PDT to be effective full dose must be given and it will show consistent results. It's a One time SIMPLE treatment ( 2nd time 6 months later) that must be done properly 1)Proper drug dose and 2) Maximum bladder volume expansion during treatment to ensure both that 1) entire bladder surface had enough drug contact and 2) entire bladder Urothelium was exposed to green light. Simple but both rely on using Maximum bladder volume. If this was not done, then we can say they only treated 25% of bladder surfaces and 75% were not treated. What do you expect? Next batch will definitely prove this once and for all just hope they get it right. All ImO
Eoganacht wrote: Yes. For what it's worth, I think results are still going to be spectacular. The currently deflated stock price does not reflect the actual prospects of the trial.
It's good to remember that photofrin achieved a CR rate of 50-80% at 2-3 months and 20-60% at 1-2 years. TLD1433 is a
far superior pdc than photofrin in both efficacy and safety and we can expect the CR rates for TLD1433 to be much higher than photofrin.
Now that the bladder volume screw up is behind us...
enriquesuave wrote: Given the screw up in bladder volume, it would be nice and comforting for us shareholders and the market, that the company provide an update at 9 months mark for first batch of 12 patients. That would be 3 months after each got 2nd treatment. At least 4 of 7 would have gotten optimized 2nd treatment. That may set the tone for what is to come for 2nd batch and help SP significantly. All IMO. We deserve it.
Yep...an under treatment of either just the drug or the light can be devastating to your results, but considering certain patients were under treated in regards to "both" drug & light (which explains the wide variance in under treatment of up to 154%), a 25% CR is quite a scientific achievement not to be ignored. Using a percentage of the maximum bladder volume voided should take into account better the problems with "less compliant" bladders in the elderly. PIs should now be well-versed in "filling up" the tank as opposed to giving in to its pressure ; ).
It seems the use of real-time bladder ultrasound during the procedure would assure full bladders...