RE:Updated Research Page on McFarland Labs Website Thanks Eoganacht...
Per Dr. McFarland's lab website:
Photobiology
"Using the underlying photophysics for rational design of photoactive compounds, we are able to install high levels of activity in either an oxygen-dependent (PDT) or independent (PCT) manner. To confirm their photobiological potency for any given application, we screen several human cancer cell lines across a variety of treatments – including variable oxygen tension (0.1–21% O2), multiple light sources and activation wavelengths from high energy blue (453 nm) to low energy near- infrared (733–976 nm), and manipulation of the light dosimetry (fluence, fluence rate, pulsed or fractioned, bandwidth). Through our application-driven and interdisciplinary approach, we have already successfully identified TLD1433, the first Ru-photosensitizer to undergo clinical trials (Phase II, clinical trial identifier NCT03945162), and continue to push the limits in light-activated therapies."
Would like to see TLT capitalize on Dr. McFarland's amazing knowledge in chemistry in the form of a JV between her private company, PhotoDynamic Inc., & TLT (majority partner). The goal would be to develop nano scintillation tech to allow this superior photosensitizer (PS) to be activated by x-ray. An interesting solution was presented way back in Nano Letters (3/12/2015) that utilized readily available elements, including an x-ray converting phosphor at the core of a two-layer silica-based structure that contained an outer porous layer loaded with PS. Perhaps HPQ Silicon Resources could provide the purified silica ; )
The phosphor (i.e. doped Strontium Aluminate) is considered non-toxic/biologically inert & essentially converts x-ray photons into visible photons, a process call x-ray excited optical luminescence (XEOL). This readily available phosphor converts x-ray photons into peak wavelengths of 520 nm (I.e. green light...sound familiar ; )...this is the precise wavelength that activates TLD-1433. Such XEOL would add immeasurable value to our current ACT tech imo.
I'll let the financially savvy here figure out the financing of such invaluable tech. GLTA...