RE:Urgent need for vaccine against COVID variants: There seems to be waning long-term protective immunity with repeated boosting, which highlights the urgent need for alternative vaccines. The article below also points to the urgent need for developing safe "non" mRNA-based vaccines against SARS-CoV-2/variants in order to minimize adverse vaccine effects.
In other words, our tech is still very much in play in view of the ongoing need to develop both effective & safe alternative vaccines that provide longer-lasting immunity. The following is a long read so I only included the written & graphical abstracts....
Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs
Author links open overlay panelStephanieSeneffaGregNighbAnthony M.KyriakopouloscPeter A.McCulloughd - a
- Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA, 02139
- b
- Immersion Health, Portland, OR, 97214, USA
- c
- Research and Development, Nasco AD Biotechnology Laboratory, Department of Research and Development, Sachtouri 11, 18536, Piraeus, Greece
- d
- Truth for Health Foundation, Tucson, AZ, USA
Received 9 February 2022, Revised 3 April 2022, Accepted 8 April 2022, Available online 15 April 2022, Version of Record 19 April 2022.
Handling Editor: Dr. Jose Luis Domingo
ABSTRACT
The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.
Graphical abstract