Theralase Technologies Inc. V.TLT

Nice Read

[enriquesuave]

https://onlinelibrary.wiley.com/doi/full/10.1111/php.13253#.XuqjyTYFaLU.twitter

[vestor111]

I like where this is going.. In addition, immunogenic cell death (ICD) caused by PDT releases damageassociated molecular patterns (DAMPs) that activate innate immunity, which leads to activation of adaptive immunity (8, 9). Henderson et al . have shown that PDT regimens can be developed to activate antitumor immunity (5). Multiple studies have linked PDTinduced acute inflammation

[vestor111]

Bummer I see no TLT/Rutherrin related research or researchers in the references. The author S. O. Gollnick appears a very prolific author in this field. Roswell Park CCC in Buffalo has been mentioned as an ideal partner for the TLT Ph2 trial in the US and not far from Toronto.  

[CAinPlap]

Yes it is somewhat disappointing we do not seem to even be on the radar within our own scinetific community.

[CAinPlap]

Sorry that should read scientific.  Getting tired of being the Rodney Dangerfield of the PDT space. We need to get the trials going so that more data can get the buzz going.

[Eoganacht]

I'm guessing there will need to be some catch-up in 18 months or so, by those who do not yet have TLD-1433 pdt on their radar. May I suggest... Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433 TLD-1433 photodynamic therapy for BCG-unresponsive NMIBC - Presented by: Girish S. Kulkarni,

[LaserStock29]

Are we 18 months away from breaking the .20 to .60 rangebound games or will the TMO 6 hospitals, fast track... nova scotia (another day of no cases btw) maybe some interim interim be enough to crack 20% of a 20% of a 4b bladder cancer market......... 200m cap

[Hempdoc]

  You read my mind ; ) The IT brigade wants the public to think of PDT as a potential adjuvant to IT, or even delineate IT/checkpoint blockade as a "much-eeded" adjuvant to PDT.  However, your last reference re: RuVaCare highlights why we could replace IT altogether.  Our anti-cancer vaccine demonstrated an excellent survival rate in the rat glioma model, & as you

[Hempdoc]

  To clarify the value of what we have...TLT has created an arsenal of therapeutic options to fight cancer.  We have our patented frontlines in TLD-1433, newer TLD derivatives, optimized PDT & possibly other forms of activation (x-ray, etc) & also our promising reserves consisting of sequential PDT/other activators +/- serial vaccination.  Now that's a one-two punch

[vestor111]

and patents that cover the waterfront.  

[Quattro74]

Yes and not just Cad & US patents. Hey don't we Have an FDA IND going on? Lol. So what IT is out there? Keytruda? I think its durable CR % maxes at ~ 30% depending on the indication. Hmmm, yep. No brainer Home Run!

[CAinPlap]

Yup we are hitting home runs in spring training batting practice where no one sees it but the training staff. We need the regular season to start where the games are televised, fans in the stands and post game coverage by the media. Based on our spring training results, we should be World Series favorites! ;) This analogy brought to you by the sports fan withdrawal support group.

[Quattro74]

Yep, definetely withdrawals. MLB is a bad omen for TLT right now. :-( Once ~ 50-60 patients have their 90 day CR data in and the first few of the 12 have their 1Yr CR data, should get interesting for SP. Especially since a good cunk of those patients will be US based.  $$$

[O12009]

It's time to put the rally caps on

[menoalittle]

>> It's time to put the rally caps on yeah, well... sellers sure do appear to be exhausted. ... but buyers are also tired as all 'ell (which I'll attest to...) so I don't know what it's time for.   ...the weekend, evidently. Must be five o'clock somewhere... (or somethings like that...) pour me another one... lol.

[langosta1]

When in need of a bit of, 'Hair of the dog" there is an old sailor expression. "Somewhere the sun is over the yardarm"  (Noon hour). So I'll drink to that. 

[StevenBirch]

Yes definitely feeling sports withdrawal instead settling for reruns of classic, and some not so classic games. While before my time baseball fans will remember Bobby Thomson's 'shot heard 'round the world' and maybe that will be TLT sooner rather than later. Everything seems to be falling into place and it's just a matter of when and not if - I think there is almost zero

[vestor111]

So much of a homerun, some big pharma cos who bet big time on IT might have to change their underwear.   One, two, three, four, I declare a bidding war.  :-)  

[Hempdoc]

  I would say the article is just a reflection of the ACT era we find ourselves in....this B rated movie stars immunotherapy, not PDT.  PDT acts as the extra or "adjuvant" to immune checkpoint blockade. Again, the immunotherapy brigade got it backwards. Sure, PDT can work as a nice adjuvant if your photosensitizer is NOT TLD-1433.  The beauty of TLD-1433 is in its

[NorCalTommy]

thanks Enriquesuave!  wow.... my eyes are glazed over after reading all of that -'as a layman '   I guess to boil it down it says in so many words that PDT has been around for awhile and much research has been done in the last few years and that research is encouraging, etc. etc....   very encouraging....  but it just seems like TLT moves at about 1/2 pace of

[skyhawk1]

Look for 2020-2021 FIREWORKS, if we RESUME & "GET CRACKING" soon in the good 'ole US of A!! Canadian data results will start the "ball rolling" & the US results will get us "fast track"!  

[vestor111]

TLT is dealing with layer upon layer of bureaucracy and regulation so yeah it is slooooooow.  But I think/hope we get noticed and rolling long before 2025...  But having said that, I wonder how many indications will be pursued at that point?  I would think if GBM - for example get announced this year and due to the nature of that death sentence gets trialed with urgency with