Theralase Technologies Inc. V.TLT

Let the 450 day CR% numbers talk.

[wildbird1]

If you want to feel good about your investment in TLT, always recheck the 450 CR% numbers.

2Q2020.......90DayCR%   =   25%CR.........450DayCR%.......(No data yet).
1Q2021...............".............=   33.3%CR...............".................(No data yet).
3Q2021...............".............=   42%CR..................".................12%CR
April,2022............".............=   44.7%CR..............."................18.4%CR.
Aug,2022.............".............=   50.7%CR..............."................21%CR.
Nov 2022.............".............=   53%CR.................."................28%CR.

1) The FDA know that as more optimized patients are treated the 450day 28%CR will go up.
2) Big Pharma also know that as more optimized patients are treated the 450day 28%CR will go up.
3) We must keep in mind, that every time the 450day CR% goes up, the $value of a big pharma deal goes up.
In short...Big pharma can't afford to wait too long to engage in a money deal talk with TLT.
4) Many doctors refuse to recommend the use of Keytruda for their patients.
5) The FDA has to find an affordable alternative to Keytruda, or many patients will needlessly die because of a lact of better treatments.
6) The time is ripe for the FDA to consider giving TLT treatment a chance with BTD.

Note: I don't worry about the SP or financing, as we all know that it is the 450dayCR% that will determine TLT future, and the 450dayCR% numbers are getting better and better, and nobody on this board can contradic that fact.

From 12%CR to 28%CR at 450day in approximately 12 months(140% increase).
Ask yourself, with more optimized patients treated, what will be the 450dayCR% in 6 or 12 months, and does the FDA already know the answer to that question?

Understanding that the FDA & Big Pharma are aware that the 450dayCR% numbers are increasing steadily, always give me a good and reassuring feeling about my investment in TLT.

[chry200030]

When will it be 450 day?

[O12009]

Each time a new Patient reaches 450 days after there first treatment. Since the numbers that has been quoted ,There are many patients reaching 450 days. The first 12 patients ,treated at the start of the Phase 2 trial , were under treated. Since then they are receiving the optimized treatment. So moving forward the 450 day numbers should keep improving. We will see those numbers before April 28.

[N0taP00p]

Chry2000030, here is a cut and paste from a previous post. My best guess. It all depends on the point in time they pick to submit data. Eoganacht estimate was closer to ~29-30% CR at 450 day, which keeps the wildbird1 progression alive.  Let's hope for the best.  "Not clear if they will use the data as-is from the ASCO poster to submit a request for BTD, in which case 450 day

[StevenBirch]

Nicely done Wildbird.

[BlueFranky]

Wildbird- Beauty post!

[CancerSlayer]

  Thanks & well stated wildbird1.... The need for additional funding is a given & should have little impact on TLT's future.  One also can't  deny our improved CRs with optimization.   I also think Keytruda won't make a dent in the NMIBC market due to its relatively low efficacy & high cost....the fact is, many urologists appear to be currently

[Rumpl3StiltSkin]

Geez Slayer, All those treatments and it is a toxic chemo treatment. Not really a BCG replacement IMO, let alone 1433.

[Yajne]

I agree that TLD1433 definitely tops altenatives. However, it still depends on an FDA decision...and that's what worries me

[steamfitter]

So Canada should go alone with the discovery. Americans will be beating down the door for the cure. It won't take long for the FDA to then approve. Just my opinion. 

[steamfitter]

So Canada should go alone with the discovery. Americans will be beating down the door for the cure. It won@t take long for the FDA to then approve. Just my opinion.@

[Oden6570]

I expressed similar thoughts several weeks ago. Were does Health Canada fit in here ? On Bended Knee ? 

[StevenBirch]

Reminds me of Raging Bull where the mob won't give LaMotta a title fight unless he takes a dive for them first so they can make a lot of money off him. But big government agencies and big pharma could never be the same as the seedy world of boxing and the mob could it? The difference is one is sport and one is the public good so would they really hold this back OR is it more a question of how

[ScienceFirst]

Wildbird1 ... Excellent post

[Eoganacht]

Great post wildbird1 ! Our efficacy results already beat both of the FDA approved treatments in our space - Keytruda and Adstiladrin - and our efficacy numbers are still improving, so, as many have noted, it's now a question of when, not if we get FDA approval. The trial results cannot be denied. I believe the reason our efficacy numbers are improving is because as more and more patients are

[Eoganacht]

That Table didn't come across very well:                             Keytruda    Adstiladrin    TLD1433 Current   TLD1433 Projected CR at any time         41%            51%                 

[enriquesuave]

We also have IR patients who can be reclassified as either CR or NR and if CR would further increase our CR % rate.

[Rumpl3StiltSkin]

in TLT's case that 38% CR number should have an asterisk next to it in any press. As we all know here, 1433 can be endlessly retried until it does work/becomes Durable...