Theralase Technologies Inc. V.TLT

Dr. Ashish Kamat Interview - BOND-003 Study Results

[Eoganacht]

[url=https://www.urotoday.com/video-lectures/non-muscle-invasive-bladdercancer/video/mediaitem/3799-bond-003-phase-3-results-revolutionizing-bladder-cancer-treatment-with-intravesical-cretostimogene-grenadenorepvec-monotherapy-for-high-risk-bcg-unresponsive-nmibc-mark-tyson.htmlhttps://www.urotoday.com/video-lectures/non-muscle-invasive-bladdercancer/video/mediaitem/3799-bond-003-phase-3-results-revolutionizing-bladder-cancer-treatment-with-intravesical-cretostimogene-grenadenorepvec-monotherapy-for-high-risk-bcg-unresponsive-nmibc-mark-tyson.html]BOND-003 Phase 3 Results: Revolutionizing Bladder Cancer Treatment with Intravesical Cretostimogene Grenadenorepvec Monotherapy for High-Risk BCG-Unresponsive NMIBC - Mark Tyson[/url]

In this trial patients are treated many times.

"... in terms of treatment, patients underwent six sequential weekly instillations of creto, followed by a second induction course for non-responders or maintenance for responders, and maintenance was at three, six, nine, 12, and 18 months."

In this interim analysis of 66 patients the results were very good but not much better than Ruvidar PDT . The CRR at 12 months has not yet been revealed but the CR at any time, 6 month CR and 9 month CR numbers were announced. The 9 month results (which go unmentioned in the interview) are available from the swimmers plot at:

 https://www.urotoday.com/conference-highlights/suo-2023/suo-2023-bladder-cancer/148306-suo-2023-late-breaking-abstract-first-results-from-bond-003-a-phase-3-study-of-intravesical-cretostimogene-grenadenorepvec-monotherapy-for-patients-with-high-risk-bcg-unresponsive-nmibc.html

CR at any time = 76%
CR at 6 months = 64%
CR at 9 months = 50%

In comparison, the optimized results of Ruvidar PDT are:

CR at any time = 67%
CR at 6 months = 60%
CR at 9 months = 50%
CR at 12 months = 36%

It's very cleat that Ruvidar PDT complete response rates hold up much better than those of CG0070.

At 9 months Ruvidar PDT has caught up with CG0070 in terms of durable complete response. When the 12 month BOND-003 data is revealed, Ruvidar PDT should have a better durable response rate than CG0070, despite the punishing treatment regime required to produce it..

[Eoganacht]

For some reason the interview link didn't come across. Here it is again: https://www.urotoday.com/video-lectures/non-muscle-invasive-bladdercancer/video/mediaitem/3799-bond-003-phase-3-results-revolutionizing-bladder-cancer-treatment-with-intravesical-cretostimogene-grenadenorepvec-monotherapy-for-high-risk-bcg-unresponsive-nmibc-mark-tyson.html

[riverrrow]

Well, that's kind of depressing.  Another competitor for Ruvidar.  Is Ruvidar 10 years too late?

[Eoganacht]

Ruvidar PDT is far superior in number of treatments and I believe it will prove to have far better durable efficacy. Ruvidar PDT requires only a few treatments while there seems to be no end to CG0070 treatments which displays a progressively weaker response over time.

[DJDawg]

I took the BOND-003 data, re-organized and added in the treatment schedule so you can appreciate that this is a treatment option but I agree wit Enrique - many pseudo CR results likely. See image below. Direct link https://i.postimg.cc/3NPcsTQQ/BOND-003-treatment-protocol-and-results.jpg

[DJDawg]

corrected thumbnail I took the BOND-003 data, re-organized and added in the treatment schedule so you can appreciate that this is a treatment option but I agree wit Enrique - many pseudo CR results likely. See image below. Direct link https://i.postimg.cc/3NPcsTQQ/BOND-003-treatment-protocol-and-results.jpg

[DJDawg]

And Ruvidar so far. Two treatments. https://i.postimg.cc/ydFq7xnY/Ruvidar-so-far.jpg

[Longholder99]

Hopefully the FDA doesn't get fooled by pseudo science and whitewashed results.

[Eoganacht]

I forgot to remove the 6 pending patients from the BOND-003 numbers - so they actually achieved 55% CR at 9 months while the optimized Ruvidar patients achieved 50% CR at 9 months. But the trend is clear.

[Gman620]

Seems like they got a good sized study population pulled together pretty quickly. So which study would you join if you were in that situation and had the offer from both? 

[enriquesuave]

Ruvidar by far given the much lower frequency of treatments 1-3 Vs many more for up to 2-3 years.  Virtually same efficacy.  

[wildbird1]

Enriquesuave, I think that once TLT has fine-tuned the treatment protocol, one treatment in most case will be enough. Pressrelease Oct 16,2023 Here is what Dr.Mandel(TLT Chief scientific Officer) said on the number of treatment necessary to achieve CR. '' Theralase has been able to demonstrate strong efficacy in the form of a CR or IR, with well-tolerated safety profile, after

[DeathXray33]

It seems all these so called treatments are just scrub-n-wash over & over to no end. They would probably have the same results using beer. They should call it BEER-003. 300 treatments of beer... Not even in the same universe as us. In fact, I think we might have extraterrestrial technology...

[riverrrow]

Thanks for your posts everybody.  I forgot how some researchers present misleading data.  75% of 75% is a little over 56%.  Our CR at 270 days is 46%.  I've suggested previously that once Ruvidar is FDA approved clinicians will be able to repeat Ruvidar treatment multiple times on a patient and quite possibly achieve 100% CR.  GLTA.

[DJDawg]

One reason that all the urologists still look at this and think "great!" is that they are locked into immunotherapy thinking from day 1. BCG, the first line agent is a bladder instillation. Induction: once a week for 6 weeks. Maint: High risk: weekly for 3 consecutive weeks at 3, 6, 12, 18, 24, 30, 36 months So 6 + 3 + 3 + 3 = 15 instillations in first 12 months. Another 6 in teh

[stocksnbonds458]

LMAO!! Death, you just set the record for the funniest and yet most erudite post in the history of this TLT Board. Beer it is!!  I rarely see posts like riverrow's, as I have most of these knuckleheads on iggy. Ruvidar is best in class and will soon have its day. 

[enriquesuave]

The constant need for maintenance treatments leads one to deduct that they probably have a lot of pseudo CR's.  If they would stop treating after induction CR rates would probably drop considerably going forward IMHO  Basically this treatment it's like saying we should retreat every 3 months with Ruvidar, as we would probably maintain 67-80% CR rate so long as you keep treating

[Alamir1111]

Thanks Eog.would be nice to have Rdw interwiuved and get Tlt results out to mainstream media.