" Live From New York"......Dr. Cruz Webcast Quips
Here are some of Dr. Cruz's Quips from the live webcast the other day gathered from all the posters who contributed.
Personal Comments from contributing posters next to the bottom......
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---"Transition completed last summer an Early Exploratory Phasel in Canada basically to look at the Pharmacokinetics."
---"Since then we've completed the FDA Approved Single Ascending Dose Study's for AZD-103."
---"We are just about done the FDA Approved Multiple Ascending Dose Study's. So we have, he says, definitely given our AZD-103 Drug to over 100 healthy volunters with different Dose Ranges and for different periods of time."
---"We are currently still completeing a few Phasel's looking at the levels in the Cerebral Spinal Fluid (CSF) and what the effects of diet are."
---"That all should be completed I would think by the middle of May to end of May."
---"There is One More Preclinical study left to complete and that is the Highest Feasible Dose and that we expect to complete in July."
--"We expect to initiate a Phasell in second half of 2007 and we are currently Designing the Phasell, in much more detail, with Elan."
---"AZD-103 is easy to produce. It is a Single Step Synthesis with just One Purification Step. This enables us to produce it at very low cost which will be Important for Alzheimers."
---"We have been given Fast-Track Designation for AZD-103."
---"Even at the Highest Feasible Dose of AZD-103 we have been able to achieve 90%-100% absorption through the gut."
--- "60%-70% of an AZD-103 dose makes it to the Brain because it is very similar in Molecular Structure to the Transporter (myoinositol?) it piggy backs on that is in the Cerebral Spinal Fluid that helps it cross the Blood-Brain Barrier."
---"Most CNS Drugs achieve only 1%...2%...maybe 3% brain levels"
---"We have the option to Increase Transitions share of
Participation from the current 30% and THIS IS OUR PLAN but we will not do it until we HAVE to do it....until we are Forced Contractually to do it."
----"We are also developing G1 which is Gastrin alone in Typell Diabetics and also planning a G1 & Byetta, a combination therapy."
----"We have already done the Phasel's for Gastrin Alone and there is no Adverse Events at any of the doses there were no adverse events. There is no nausea or nothing of things that are often associated with the other Factors. We plan to do our first Phasell sometime in the 3rd Quarter this year. This is G1 and Metformin/TZD a 3 month study and really looking at the efficacy in Typell Diabetes."
----"Our second Phasell Study would be G1 plus Byetta and we are now in discussions with a few partners that are interested in these technologies to see how we might move these forward together."
----"We are Initiating a G1 and a GLP1-INT Phasell clinical trials.
We are submitting, actually, a Protocol right now to the FDA to Initiate or start discussions Initiating these programs and at the same time we are looking at potential partners who are experts in these areas to work with us and move these programs forward."
---"AZD-103 has now been administered to over 100-120 Humans."
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---"Good presentation. He led off with AZD-103. He also sounded very optimistic that Novo would sign on for E1-INT. Cheers."
---"Tony Cruz did say 2day that commercial milestones for the E1-INT product from the NN partnership are $85M US. "
---" TC was interupted more than once during his presentation and asked for clarification. It shows that people in the audience were actually listening and were interested in the content, not just thinking about lunch."
---"~~~~TONY CRUZ SAY APPLY TO FDA TODAY FOR PHASE2 FOR GASTRIN AND APPLY TODAY TO FDA FOR GLP1-INT FOR PHASE2~~~~~I BELIEVE TONY CRUZ "
---""This is the part I really like.....being able to buy back retroactively a Higher Percentage of Participation AFTER seeing the Trial Data !!! Come to Pa-Pa ...........here it is as per Dr. Cruz.
---They have the option to Increase Transitions share of
Participation from the current 30% and THIS IS THEIR PLAN but they will not do it until they HAVE to do it....until they are Forced Contractually to do it.""
---"TTH did get a mention in a recent CIBC brokerage report, so it might be the start of a larger brokerage following of the stock."
---""....banging the drum hard just prior to Alzheimers Trial Results. Wouldn't be surprised to see him on BNN in the next few weeks. ""
---"It's almost a GIVEN...NN will exercise the option. TC is building a great co. here..."
---""I find this next part of the presentation very intrigueing in that they are Initiating a Stand Alone Phasell Trial with Gastrin (G1) for Typell Diabetes and the Phase1 is done already with zero-nil-nada-No Nausea At All as is commonly found with all the other similar treatments""
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My latest favorite Dr, Cruz Quote.........
..........."----We are Initiating a Phasell G1 Gastrin Alone AND a GLP1-INT Phasell clinical trials. We are submitting, actually, a Protocol RIGHT NOW to the FDA to Initiate or start discussions Initiating these programs and at the same time we are looking at potential partners who are experts in these areas to work with us and move these programs forward."
Could see this parnership for GLP1-INT any time now folks.......Like Dr. Cruz says GLP1-INT Phasel is complete for all intents and purposes.