AZD-103 Prevents Neuronal Cell Death.....Wow
AZD-103 doesn't just prevent the plaques seen in Alzheimers.....it Prevents Neuronal Cell Death. https://www.jneurosci.org/cgi/content/full/27/11/2866#B44
I like this quote here from Dr. Cruz........."Dr. Joanne Mclaurin (Inventor AZD-103) was looking at Neuronal Toxicity where Amyloid binds to Neuronal Cells and kills the Neuronal Cells and what she found was that if she added AZD-103 it PREVENTED the Neuronal Cell death. Then what she found was that to create Neuronal Cell death you need Fibrils (Oligomers) to come into contact with the Neurons. Just free Amyloid (Monomers) is not sufficient. What she found was that when she added AZD-103 was that it Broke Up the Fibrils." .......There we have the simplest explaination yet for this potential blockbuster drug.
McLaurins Findings were put to the test and taken a few steps further to find the Mechanism of Action when it was shown that AZD-103 completely REVERSED the Cognitive Impairment in a couple of separate but very different Cog tests...... one of which was run by Selkoe. So then in the Study 'Shankar et al 2007' including Dr. Selkoe showed that it prevents Synapes Loss!! Anyone that hasn't read this study really should. It shows that Monomers (regular Amyloid) DO NOT cause Neuronal Cell Death!! What it does show is that when Amyloid starts to Aggregate into Oligomers in the brain, specifically Dimers and Trimers in this study, that is when you can start to see the Neronal Cells Die and ultimately Synaptic Failure. This is when the memory starts going. MCI btw is estimated to be an even larger market than AD is......Perhaps 4 times as large.
Oh...... and when the Shankar et al scientists introduced AZD-103.......well it REVERSED the effects that the Oligomers had on the Neuronal Cells and Dendritic Spines and stopped Synaptic Failure. Bang.