RE: # 11.....TYPE2 is the Chosen Path...
Forgot to mention...........xIt's in your inbox.....
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2bmb.....I have a list thats a bit longer for GLP1 Co.'s.........OK found it
OK 2bmb...... Januvia isn't a GLP1 Analogue . It is a DPP-IV Inhibitor. GLP1 has a short half life in the body because it is degraded easily by DPP-IV resulting in a half life of mere minutes. By Inhibiting the DPP-IV the body's GLP1 is afforded a longer half life resulting in it's ability to release more Endogenous Gastrin(TT223)and therefore the Differentiation and Preservation of the insulin producing Beta-Cells, thus improving Glucose Control.
This is WHY TT223 is getting it's very own Phasell Trial in TYPE2 DB very soon.......supporting studies are COMPLETE. We await results.
TT223 has also already shown in combo with another Analogue in Phasell Trials in Humans to act on Islet Precurser Beta-Cells through a process called Neogenisis. That is the New Growth of Insulin Producing Cells. Not just the re-activation of dormant Beta-Cells as shown above. For those patients in the Human Trial that showed a drop in HbA1c levels of greater than 1% in the OGTT (oral glucose tolerance test) from baseline....... they showed that their own body increased IT'S VERY OWN Insulin Production >60% 1st Month---- >95% 2nd Month---->90% 3rd Month--- >40% 4th Month...... all after a 28 day Treatment Period. Never been done before!!!
This showed Proof Of Concept for TT223 in Humans.
Mechanism of Action was Validated for TT223 in Humans.
NeoGenisis (Regeneration) of Islets was Shown as a result of TT223 in Humans. These results certainly warrant a further larger Phasellb Trial......in TYPE2.
...... BUT TT223 Stand Alone ion TYPE2 is more important at this point in Unlocking the Value of this Drug Platform as is GLP1+TT223 in TYPE@ DB. TYPE2 Diabetes accounts for 90-95% of all Diabetics.....Management is leading us down the right path IMHO.
Stand By #11..... It's in your inbox.
GPP All