4601 magic
IV infusion = sustained level of 4601 is blood and plasma, leading to accumulation in brain tissues.
PBR lingand = selectiviy of 4601 to concentrated on GBM cells.
Now, PBR also opens the door for 4601 to enter into cells.
2 remaining questions
Will 4601 degrade and loose potency.
Is GAS-GDP inhibition the sweet spot.
In vivo and in vitro models say that 4601 should operate without degradation and should block multiple pathways; cancer cells will stop exponential duplication and will start self destruction.
If delivery is perfect and assuming that 4601 is very stable, it should work.
SP will start going up as trial progress. Everyday with no cancellation of trial news equal higher odds of success.