4601 - Effective on Metastatic Cancer
Efficacy data from PI trials are not easy to interpret
https://www.ecopiabio.com/docs/publications/17.2007-ISC.pdf
There is one cancer type more deadly than GBM - that's when a cancer enters the metastatic phase.
https://emedicine.medscape.com/article/280505-overview
compare media survival time with
https://en.wikipedia.org/wiki/Glioblastoma_multiforme
Dosing regimen was not optimal in PI, because the purpose was assess toxicity first.
TLN scientist decided to take a bold approach for efficacy.
Assumption was if 4601 is efficacious in metastatic cancer patient, broad effect will be confirmed and high cytoxity will also be confirmed.
And they got what the wanted.
- 6/7 SD (stable disease)
- Anecdotal evidence by investigators observations
GBM was the top choice at tha time too.
Assumption was if 4601 shows efficacy in SD it will show the same kind of results on GBM, knowing that Metastatic cancer is more dealy and potent than GBM