Medicago Inc MDCGF

RECOMBINANT PROTEINS/BIG PHARM

[SHARKFACE]

Alfalfa

We have also developed a technology for the production of recombinant proteins in transgenic alfalfa. Transgenic alfalfa is best suited for the production of recombinant proteins required in high volumes and for which a relatively long lead time – up to six months – is not an issue. While this technology is not suited for the production of vaccines, we believe it may have applications in other field of interest such as the production of enzymes for biofuels.
MEDICAGO WEB SITE
-------------------------------------------------------------------------------------------------------------------------------------------------------------
WIKIPEDIA
==================================================================================

List of recombinant proteins

From Wikipedia, the free encyclopedia

Jump to: navigation, search

Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature

[edit]Human recombinants that largely replaced animal or harvested from human types

• Human growth hormone (rhGH) Humatrope from Lilly and Serostim from Serono replaced cadaver harvested human growth hormone
• Biosynthetic human insulin (BHI) Humulin from Lilly and Novolin from Novo Nordisk among others; largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal-sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce hypoglycemia unawareness. Remaining manufacturers of highly-purified animal-sourced insulin include the U.K.'s Wockhardt Ltd. (headquartered in India), Poland's Polfa Tarchomin S.A., Argentina's Laboratorios Beta S.A., and China's Wanbang Biopharma Co.
• Follicle-stimulating hormone FSH replaced Serono's Pergonal which was previously isolated from post-menopausal female urine
• Factor VIII Kogenate from Bayer replaced blood harvested factor VIII

[edit]Human recombinants with recombination as only source

• Erythropoietin (EPO) Epogen from Amgen
• Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen from Amgen; pegfilgrastim sold as Neulasta
• alpha-glactosidase A Fabrazyme by Genzyme
• alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme by BioMarin Pharmaceutical and Genzyme
• N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) by BioMarin Pharmaceutical
• Dornase alfa, a DNase sold under the trade name Pulmozyme by Genentech
• Tissue plasminogen activator (TPA) Activase by Genentech
• Glucocerebrosidase Ceredase by Genzyme
• Interferon (IF) Interferon-beta-1a as Avonex from Biogen Idec; Rebif from Serono; Interferon beta-1b as Betaseron from Schering
• Insulin-like growth factor 1 (IGF-1)

[edit]Animal recombinants

• Bovine somatotropin (bST)
• Porcine somatotropin (pST)
• Bovine Chymosin

[edit]Viral recombinants

• Envelope protein of the hepatitis B virus marketed as Engerix-B by SmithKline Beecham