RE: Tekirma pops on a cure for Ebola VirusI checked on AVII... they do not in fact have 100% success with Ebola...as they do with Marburg. Here is what they say.
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In repeated trials, monkeys were dosed with well–tolerated amounts of drug and survived a challenge of roughly 1000 times the minimum lethal dose. This level of infectious challenge normally results in uniform death of untreated monkeys within 7 to 10 days. Treatment of Ebola infected animals with AVI–6002 resulted in 75 percent survival of the infected animals at 15 days post infection when the treatment period ended and circulating viral titer was below detectable levels. Treatment of Marburg infected animals with AVI–6003 resulted in 100 percent survival at 15 days.
The majority of the collaborative research effort between AVI and USAMRIID has been supported by a research contract from the Department of Defense’s Transformational Medical Technologies Initiative (TMTI) with the goal of developing a new antiviral (antisense) platform targeting hemorrhagic fever viruses. In addition to development of antiviral agents for Marburg and Ebola, AVI is receiving government funds to develop antiviral agents to treat Junín virus under this contract. Under separate government agreements, AVI is receiving support for programs in Junin virus, Dengue virus, the H1N1 virus, anthrax and ricin, as well as for additional applications in Ebola and Marburg.