Sirona Biochem Corp V.SBM

Diabetes and Obesity Therapeutics - SGLT2-inhibito

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Development Pipeline

Sirona Biochem specializes in the development of carbohydrate-based molecules. Our partner, TFChem, and their award-winning synthetic chemists have developed a proprietary chemistry technique with an aim to improve these typically finicky molecules.  While carbohydrate-based molecules offer immense commercial potential, the focus will be on three programs – diabetes and obesity therapeutics, anti-aging cosmetic ingredients and biological ingredients.

Diabetes and Obesity Therapeutics - SGLT2-inhibitors (Sodium-Dependent Glucose Transporters)

Together with TFChem, Sirona Biochem is developing SGLT-2 inhibitors for Type 2 diabetes and obesity. SGLT inhibitors are a potential new class of drugs for diabetes and obesity. They work differently from traditional Type 2 diabetes therapeutics which increase insulin production in the pancreas. In the kidneys, SGLT inhibitors reduce the reabsorption of glucose into the bloodstream by excreting excess glucose into the urine.

The kidneys filter approximately 180 gm of glucose per day from the blood which is then mostly reabsorbed back into the blood. SGLT Inhibitors inhibit the glucose reabsorption process, such that excess glucose is excreted in the urine, rather than reabsorbed into the bloodstream. That is to say, they have a hypoglycemic effect. This is a new promising potential treatment for Type 2 diabetes and obesity. 

Sirona Biochem is conducting preclinical tests on an SGLT-2 inhibitor for diabetes and obesity. While there is no SGLT-2 inhibitor currently on the market, the most advanced drug candidate of its kind is in Phase 3 clinical trials. Sirona Biochem aims to develop an improved, best-in-class product.

Cosmeceuticals - Anti-aging ingredients

Our partner TFChem is applying its chemistry methods to develop anti-aging cosmetic ingredients.  We believe our carbohydrate-based molecules may be able to maintain the viability of adult skin fibroblasts by protecting the fibroblasts from oxidative stress and UV radiation.

Biological ingredients

Sirona Biochem believes that there is a large market potential for the development of carbohydrate-based molecules for biological manufacturing.  We feel this chemistry technology can be used for the development of laboratory solutions, organ transplantation and for the preservation of stem/islet cells.  This could be valuable in the production of insulin, human growth hormone, vaccines, interferon (anti-viral/bacterial/parasitic/tumour) and interleukin-2 (immune).