Back to Basics The quality of the discussion seems to have deteriorated. While everyone has been trading insults, I have been doing some research to teach myself the basics. Silvarline said I was a Layman. True. But that suggests we have some Urologists on this board. Excellent.
This post and others to follow are for Laymen like myself. All you experts can stop reading now.
While I waited for March results to tell me how the company was progressing, I have been reading original articles (where available) on P2 and P3a results for Urocdin. I have also been teaching myself about efficacy/CR/DFS statistics, Intent To Treat population vs Efficacy Evaluable population, Investigator Bias and Type I vs Type II errors in statistical analysis of clinical studies. I found some cool stuff that I have not seen on this board before, certainly not in the last 3 years.
To begin at the beginning, when the doctors suspect you have bladder cancer, because of symptoms like blood in the urine, they do a TURBT operation to take a look and remove the possibly cancerous growths. Here is a YouTube video of a TURBT operation. It is 42 seconds long and has no blood. It shows how they remove a papillary growth. This is the type for which P3a showed a 35% disease free survival (DFS). There are other videos similar to this one on YouTube. I found one that looked like carcinoma in situ (CIS) but it looked more disturbing. Here is the papillary video. For all us Laymen:
www.youtube.com/watch?v=867bznm9WXw
Bullish and [redacted]