Sure they do. What ever happened to LymphExpress, may just happen with LungExpress or GeneDx.
Tell us what sales have they experienced with LungExpress? You people don't know what is needed for a successful launch here do you? This is a momo play, but it's gotten well above where I sold over 3 years ago, so it seems to have worked well. GL
VANCOUVER, BRITISH COLUMBIA – Med BioGene Inc. (TSX Venture: MBI), a life science company focused on the development and commercialization of genomic-based diagnostic tests for cancer and cardiovascular disease, today announced results from a recent study that confirm the previously demonstrated high accuracy rate of LymphExpress Dx™ v.1.0.
LymphExpress Dx™ v.1.0 is a gene expression-based array being developed to diagnose the most common subtypes of lymphoma, together representing approximately 90% of all Non-Hodgkin B-cell and Hodgkin lymphomas. In the study, LymphExpress Dx™ v.1.0 achieved a concordance rate of 88% between the conventional pathological diagnosis and that determined by LymphExpress Dx™ v.1.0. The median sensitivity was 98% and the median specificity was 85%. The overall accuracy rate of the array is estimated to be over 90% given that conventional pathological diagnoses have an average error rate across all lymphoma subtypes of greater than 15%. The MBI study involved 153 tumour samples from patients with clinically diagnosed lymphoma.
Accurate diagnosis of lymphoma is essential for determining prognosis and the best treatment options, but this presents a clinical challenge as pathologists may disagree regarding diagnosis of certain subtypes in as many as 47% of the cases. The experience and skill of the pathologist is of particular importance for accurate diagnoses. Conventional diagnosis can be time consuming and requires the interpretation of results from a battery of complex tests to render a diagnosis of the particular lymphoma subtype. Molecular diagnostic tools, such as LymphExpress Dx™, are expected to simplify and expedite the process while providing more accurate diagnoses.
MBI is currently developing a second generation prototype, LymphExpress Dx™ v.2.0. This array is being developed to diagnose additional subtypes of lymphoma, in total representing approximately 98% of all Non-Hodgkin B-cell and Hodgkin lymphomas.
“These results further validate our proprietary approach to diagnosing lymphoma by analyzing the gene expression patterns of unique biomarker panels,??? said Dr. Bradley W. McLean, MBI’s Chief Scientific Officer. “We have advanced our technology and worked with an expanded patient population to refine our gene expression signatures specific to lymphoma and have enhanced our statistical methods for choosing optimal biomarkers. These results give us greater confidence that our biomarkers will yield clinically-robust results.???
About Lymphoma
Lymphoma is a general term for a group of cancers that originate in the lymphatic system and is comprised of more than 42 disease subtypes. Lymphoma is divided into two major categories: Non-Hodgkin lymphoma, representing 88% of all lymphomas, and Hodgkin lymphoma, representing approximately 12% of all lymphomas. 85% of Non-Hodgkin lymphomas arise from B-cell malignancies and represent the most lethal lymphoma subtypes. In the United States, lymphoma is the fifth most common cancer, afflicting approximately 74,000, and killing approximately 20,500, people each year. Currently, approximately 40% of persons diagnosed with B-cell Non-Hodgkin lymphoma will die within five years. Diagnosis and treatment of patients with lymphoma costs approximately $4.6 billion per year in the United States alone, with an average per patient expenditure of $21,500 in the first year after diagnosis.
About Med BioGene
MBI is a life science company focused on the development and commercialization of genomic-based clinical laboratory diagnostic tests for cancer and cardiovascular disease. MBI develops these tests by identifying the genes, known as "biomarkers," which indicate the presence of disease. The development of these tests is the first step towards personalized medicine and will replace the conventional “one drug fits all??? approach to disease management.
For corporate information, please contact:
Erinn B. Broshko
Chief Executive Officer
(604) 306-4969
ebroshko@medbiogene.com
www.medbiogene.com
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