RE: Two Variables Trusse, First off congrats on your success with lowering your cholesterol with lifestyle interventions like diet and exercise. You indicated you went down from 150 to 107. I'm assuming you're talking about total blood cholesterol levels. 150 mg/dl is already pretty darn good, depending on your HDL/LDL split. Normal range for LDL-C is 50-130 mg/dl and most clinicians won't consider intervening pharmacologically unless LDL-C is well above 100 mg/dl. HDL-C range most is 40-60 mg/dl. So if your 107 mg/dl cholesterol is about 50/50 HDL/LDL, that is great! However your assumption that you have experience plaque regression might not be valid. If we assume most of your change from 150 to 107 mg/dl is a drop in LDL, without a change in HDL, then very likely you will effectively slow the growth of future plaque, but unless you dramatically changed your HDL, regression may be unlikely. That's what makes RVX-208 such a holy grail. It could be the first orally administered pharmaceutical that raises HDL AND is proven to stop or regress plaque formation (ASSURE results pending, of course)