Sirona's skin lightening compounds are non-sensitizers
Sirona's skin lightening compounds are non-sensitizers
2013-07-24 06:07 PT - News Release
Mr. Neil Belenkie reports
SIRONA BIOCHEM'S SKIN LIGHTENING COMPOUNDS PROVEN TO BE NON-SENSITIZERS IN SAFETY ASSESSMENT
Sirona Biochem Corp.'s skin lightening compounds are non-sensitizers.
Compounds TFC-849 and TFC-723 were tested in a skin sensitization risk assessment, which is an important component of the safety assessment of cosmeceuticals. Sensitization testing measures whether the repeated application of a compound will produce an allergic reaction or immunotoxicity to the skin.
Sirona Biochem conducted its study using a multi-parameter in vitro alternative method developed by the LMSM at the University of Rouen because no in vitro alternative method of testing has been adopted yet by EURL ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing). In the study, the compounds' sensitizer potency was evaluated using a combination of 4 parameters (resorption, haptenation, IL-18 production and cytotoxicity) and a decision table to analyze the compiled results.
Both compounds, TFC-849 and TFC-723, were proven to be non-sensitizers. The study, part of the BetaClear project, funded by a $1.9 million French grant, is led by TFChem, Sirona Biochem's subsidiary, and involves a consortium of partners.
"We are thrilled to be developing a track record of continued positive results in the testing of our compounds, with the newest results showing that our compounds are non-sensitizers," said Neil Belenkie, Chief Executive Officer of Sirona Biochem. "The support of our partners has been essential in the testing of our compounds, and we look forward to the development of a world-class skin lightening product," he added.
According to Global Industry Analysts, the global skin lightening market is estimated to be US$9 billion and is expected to exceed US$19.8 billion by 2018. Fairness products account for over 45 percent of the skincare market and it's estimated that about 15 percent of the global population invests in skin lightening products. Japan has the largest market worldwide for skin lightening, and Asia-Pacific is led by India and China as the fastest growing skin lightening market in the world.