Complex adaptive therapeutic strategy (CATS) for cancer

https://news.stanford.edu/news/2014/january/ludwig-gift-cancer-010614.html
 
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Fig. 4. 

Improvement of anti-tumor immunity by blocking CD47 on tumor cells to signal-regulatory protein-α (SIRPα) on phagocytes. CD47 serves as a “don't eat me” signal, which prevents phagocytosis by signaling through the phagocyte receptor SIRPα. Blocking CD47 may accelerate clearance of tumor cells by phagocytes.

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Corresponding author contact information
Corresponding author at: Department of Biochemistry and Cell Biology, School of Medicine, Cell and Matrix Research Institute, Kyungpook National University, 101 Dongmin-dong, Jung-gu, Daegu 700-422, Republic of Korea. Tel.: + 82 53 420 4821; fax: + 82 53 422 1466.

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