RE:RE:Interesting Article on New Heart Attack Predictor
Inflammation causes the plaque rupture. Technically inflamation causes the thinnning of the firbrous cap that surrounds the atheroma which eventually can lead to plaque rupture. Keep in mind that inflammation is a very broad term. Inflammation within the arterial wall is simply referring to the over expression of certain proteins that are part of the cascade which can lead to the rupture of the thin fibrous cap. However, plaques rupture all the time and are rarely symptomatic. The process of rupture and healing is continuously happening within your aterial wall. This process is much more detailed than I am stating here, and its not as simple as sayng that RVX-208 is anti-inflammatory and therefore it will have a similar effect as something else that is anti-inflammatory. Of note also is that when measuring certain "inflammatory" markers, it is important to undertsand that there often is a difference within the arterial wall and versus circulating in plasma. This has a huge impact and effects the choice and method of what you choose to measure as part of a study. This is why there is so much confusion over this area from one study to the next.