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Ayala Pharmaceuticals Inc ADXS

Ayala Pharmaceuticals, Inc. is a clinical-stage oncology company primarily focused on developing and commercializing small molecule therapeutics for patients suffering from rare and aggressive cancers, primarily in genetically defined patient populations. The Company's lead candidate is aspacytarabine (BST-236), a novel anti-metabolite for first line treatment in unfit acute myeloid leukemia (AML). Aspacytarabine (BST-236) is composed of cytarabine covalently bound to asparagine, acting as a pro-drug of cytarabine. It is also focused on the development and commercialization of proprietary Listeria monocytogenes (Lm)-based antigen delivery products. These efforts are primarily focused on the development of ADXS-504, a Lm-based therapy for early-stage prostate cancer.


GREY:ADXS - Post by User

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Post by MissionIRon Feb 11, 2014 6:32pm
254 Views
Post# 22197648

Advaxis, Inc. (ADXS) Engages SynCo Bio Partners for Manufact

Advaxis, Inc. (ADXS) Engages SynCo Bio Partners for Manufact

Advaxis, Inc. (ADXS) Engages SynCo Bio Partners for Manufacturing of ADXS-HPV

Today before the opening bell, Advaxis, a biotechnology company developing the next generation of cancer immunotherapies, announced it had signed an agreement with SynCo Bio Partners to manufacture Advaxis’ leading drug candidate, ADXS-HPV. Under the terms of the agreement, SynCo Bio Partners will be assisting Advaxis in development of scale-up and commercial manufacturing processes for ADXS-HPV bulk drug substance and drug product.

As Advaxis’ lead immunotherapy for the treatment of HPV-associated cancers, ADXS-HPV showed strong increased survival and objective tumor responses in a Phase 2 trial featuring 110 patients with recurring cervical cancer. In this year, Advaxis plans to begin registrational trials for patient treatment of cervical cancer with ADXS-HPV.

“SynCo’s ability to manufacture both drug substance and drug product for ADXS-HPV will offer us increased flexibility as we expand our manufacturing process in preparation for commercial-scale production,” commented Daniel J. O’Connor, Chief Executive Officer of Advaxis. “To have the support of a world-class manufacturer, such as SynCo, is pivotal to our ability to make ADXS-HPV available to patients on a global scale, upon approval.”

Pierre Warffemius, Chief Executive Officer of SynCo Bio Partners, commented, “SynCo is very pleased to enter into a long-term manufacturing collaboration and looks forward to working with Advaxis to support global licensure of ADXS-HPV. Our leading position for supply of live microbial biopharmaceuticals, through providing high quality manufacturing services, will bring this therapeutic vaccine safely to patients for the treatment of HPV-associated cancers.”

For more information, visit: www.advaxis.com

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