RE:RE:RE:RE:RE:RE:INTERESTING ARTICLE RE LIPID MANAGEMENT , DOSING START
Guess it depends on what you mean by druggable? They can be formulated with phospholipids, but if by druggable you mean given orally, yes they can. Normally peptides longer then 3 or 4 amino acids in length will not be absorbed intact in the GI, however, that probelm has been solved in a few different ways. The most well known is simply using D-sided amino acids. Amino acids produced in the body are known as L-sided. This is why when you go the healthfood store and by say L-carnitine or something, the L just refers to the orinetation. D-sided amino acids have the same linear structure but use a mirror image. This mirror image shileds them from enyzymatic degradation in the GI and in plasma for an increased time.
While pepetides are considerably cheaper than full length proteins, they are still significantly more expensiveto manufacture than small molucles like 208, so all things being equal, you would still rather have a smnall molecule from a company standpoint. From a aptient standpoint, that depends. Due to their larger size and know breakdown structures, peptides can have less side effects.