Article well worth reading if you own a dog...See excerpt (and link below).
And, hopefully the new management will know how to effectively use the information provided in this article to help get things going
(when the time is right) for Immunocidin and Sin Susto. Be very interesting to know the % of dogs (of these breeds) that experience
the serious side affects listed.
At least, good to be aware of (to ask your vet about) if they're recommending the following for your dog. rg
vetSTREET- Multidrug Sensitivity: What You Need to Know
By
Dr. Marty Becker | April 10, 2014
If you live with a herding breed, you probably know that your dog may be sensitive to certain parasite-control products, antibiotics,
sedatives,
chemotherapy drugs and pain medications. Many
Collies,
Australian Shepherds and related breeds can
suffer life-threatening illnesses or even die if given those medications. That’s because they have a gene mutation that allows these
drugs to build up in the brain, where they can cause neurological reactions, including tremors, disorientation and blindness.
What You Need to Know:
Most commonly affected breeds:Australian Shepherds (standard and miniature),
Collies, McNabs,
Longhaired Whippets and
Silken Windhounds (the latter two breeds are thought to have Shetland Sheepdog in their ancestry). Other breeds in which the mutation has been found are English Shepherds,
German Shepherd Dogs,
Old English Sheepdogs and
Shetland Sheepdogs.
Drugs to avoid in dogs with the MDR1 gene mutation: The tranquilizer acepromazine; a pain medication called butorphanol; the anti-cancer drugs doxorubicin, vinblastine and vincristine; the antibiotics erythromycin and rifampin; anti-parasitic drugs such as ivermectin (in high doses), milbemycin, moxidectin and selamectin; and the anti-diarrheal drug loperamide (Imodium).
Mixed breeds can be affected: You may or may not know if your mixed breed has herding dog ancestry. Many mixed breeds who don’t resemble herding dogs have been identified as having the MDR1 mutation. The WSU Veterinary Clinical Pharmacology Lab recommends that mixed breed dogs be tested for the mutation before receiving anti-mange doses of ivermectin, which are much higher than the doses used in heartworm preventive.
https://www.vetstreet.com/dr-marty-becker/multidrug-sensitivity-what-you-need-to-know?WT.z_mod=TOV