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Arbutus Biopharma Corp ABUS

Arbutus Biopharma Corporation is a clinical-stage biopharmaceutical company. The Company is leveraging its virology expertise to identify and develop novel therapeutics with distinct mechanisms of action, which can potentially be combined to provide a functional cure for patients with chronic hepatitis B virus (cHBV) infection. Its HBV product pipeline includes Imdusiran and AB-101. Imdusiran is its proprietary, conjugated GalNAc, subcutaneously delivered RNAi therapeutic product candidate. AB-101 is an oral PD-L1 inhibitor that has the potential to reawaken patients’ HBV-specific immune response by inhibiting PD-L1. Its pipeline includes two product candidates that target various steps in the HBV viral lifecycle and consists of various programs: RNAi therapeutic (imdusiran, AB-729) and Oral PD-L1 Inhibitor (AB-101). RNAi therapeutics utilize a natural pathway within cells to silence genes by eliminating the disease-causing proteins that they code for.


NDAQ:ABUS - Post by User

Bullboard Posts
Post by longondmxon Aug 01, 2014 12:36pm
293 Views
Post# 22803043

$22.50 US target

$22.50 US target

Clarus Securities has initiated coverage of Tekmira Pharmaceuticals (NASDAQ:TKMR; TSX:TKM) with a “buy” rating and price target of $22.50, saying the company is delivering multiple paths to value. The stock closed at $12.73 on Wednesday.

Tekmira is focused on RNA interference (RNAi) therapeutics and is a global leader in the field. The company develops a novel class of biological therapeutics and also out-licenses its lipid nanoparticle (LNP) delivery platform.

“Through extensive clinical testing and numerous high-profile partnerships, Tekmira’s SNALP LNP delivery system has become the industry gold standard,” writes analyst David Novak.

The company’s TKM-Ebola drug candidate is currently on clinical hold by the FDA. “We estimate a 75% probability of resumption and associated clinical success, representing a base case of $8 a share derived from our sum-of-the-parts (SOTP) analysis,” he said.

Tekmira’s TKM-PLK1, a highly ubiquitous cancer therapeutic, offers significant mid-term upside, he said. Currently in Phase 1/2 for three oncology indications, “we estimate a base case of $10 a share in SOTP value, assuming a 30% probability of clinical success,” he added.

In addition, Mr. Novak said that “business development opportunities and blockbuster preclinical candidates, such as TKM-HBV, represents enormous upside, free of charge.”

Citing Tekmira’s low-to-medium-risk pipeline candidates, specifically, TKM-Ebola and TKM-PLK1, he said “either one alone, combined with cash, exceeds current market value.” Tekmira had $134-million of cash at the end of the first quarter.

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