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DiaMedica Therapeutics Inc DMAC

DiaMedica Therapeutics Inc. is a clinical-stage biopharmaceutical company. The Company is focused on improving the lives of people suffering from serious diseases with a focus on acute ischemic stroke. Its lead candidate DM199 (rinvecalinase alfa) is the first pharmaceutically active recombinant (synthetic) form of the human tissue kallikrein-1 (KLK1) protein to be clinically studied in patients. KLK1 is an established therapeutic modality in Asia, with human urinary KLK1, for the treatment of acute ischemic stroke and cardio renal disease, including hypertension. It has also produced a potential novel treatment for severe inflammatory diseases, DM300, which is in the early preclinical stage of development. KLK1 is a serine protease, or protein, produced primarily in the kidneys, pancreas and salivary glands. KLK1 plays a critical role in the regulation of local blood flow and vasodilation in the body, as well as an important role in reducing inflammation and oxidative stress.


NDAQ:DMAC - Post by User

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Post by chumpismeon Nov 17, 2014 10:43am
215 Views
Post# 23135703

DiaMedica Cancels Proposed Financing...Awaiting Results of P

DiaMedica Cancels Proposed Financing...Awaiting Results of PNovember 05, 2014 20:28 ET DiaMedica Cancels Proposed Financing Awaiting Results of Phase II Clinical Trial MINNEAPOLIS, MINNESOTA--(Marketwired - Nov. 5, 2014) - NOT FOR DISTRIBUTION TO UNITED STATES NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES DiaMedica Inc. (TSX VENTURE:DMA), a clinical stage biopharmaceutical company primarily focused on the development of novel, first-in-class treatments for diabetes and kidney disease, today announced that it has cancelled its previously announced public offering for the issuance of up to 24 million units at a price of $0.25 per unit. As a result of such cancellation, no shares will be sold pursuant to the proposed offering. The financing, originally announced on October 22, 2014, had been expected to close on or about November 11, 2014. However, the Company's randomized, placebo-controlled, double-blinded Phase II clinical trial of DM199 in patients with type 2 diabetes mellitus was recently completed and it now expects to receive the results of the study from the clinical research organization in mid-November. As a result, the Company elected to cancel the financing. "After careful consideration, we made the difficult decision to cancel the proposed public offering," said Rick Pauls, DiaMedica President & CEO. "Ultimately, we concluded it would be in the best interest of all DiaMedica shareholders to report the results of the Phase II study before completing a prospectus financing. The completion of this Phase II study represents another significant milestone for DiaMedica and we look forward to sharing the results." A total of 37 patients were enrolled with 35 completing the entire one-month study. The primary endpoints of the study are to evaluate the safety, tolerability and pharmacokinetics of two dose levels of DM199. Secondary endpoints include evaluating the effects of DM199 on diabetes biomarkers including: fasting glucose, insulin and C-peptide; meal tolerance test; HOMA2-IR; HbA1c; lipids and other metabolic markers. Prior to the study, the patients complete a one-month wash out of their diabetes mediations and then are sequestered for the month-long study. About DiaMedica DiaMedica is a publicly traded (TSX VENTURE:DMA) clinical stage biopharmaceutical company focused on the discovery and development of novel therapies to treat diabetes and kidney disease. DiaMedica's lead clinical product, DM199, is a recombinant human protein known as rhKLK1 that represents a novel approach to treating diabetes and kidney disease. DiaMedica is also developing a monoclonal antibody, DM204, for the treatment of Type 2 diabetes, which is in preclinical development. DiaMedica's common shares are listed on the TSX Venture Exchange in Canada under the trading symbol 'DMA'.
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