RE:RE:RE:RE: Question for TuesdayQuattrro, I was diverted for last few hours but now I'm back. Thank you! I'd try to clear your headache 1st with aspirin but if that doesn't work, try this: (1) Nothing is req'd here... comprende? (2) The discussion was NOT about bladder cancer... that protocol is set (3) There will be a significant time period before any follow up human trials are started after the bladder cancer trial is complete (I assume that you know that bladder cancer ONLY is being trialed in ph1/2). (4) Time period- Assuming that Fast Track status is met with bladder cancer by say mid- 2016 (let's be very optimistic), you do realize that the next human trial in solid tumor will not start for another 2 years assuming financing right (that's means start in 2 years, the finish will be)? So at minimum we're talking 3 years before another solid tumor trial begins. (5) Let's leave that scenario aside for now for and review 4 PDC's TLT has on the shelf and veterinary oncology trials. Please also remember that White has made specific reference to mammalian tissue... not I. Now assuming in January 2015 you met with one of a multitude of veterinary oncology hospitals (or more than one for that matter), you could begin a low cost program to administer each of the 4 PDC's in dogs (or horses) with the same specific solid tumors of say 20mm or greater. Then quite possibly by the time the bladder trial starts, you will be able to confirm efficacy in large solid tumors. WILL THAT GET YOU FDA APPROVAL? No, no and no!! (6) What it will get you, if successful, is a.) confirmed efficacy in large tumors along with any potential immune response. b.) Pharma attention since they will know that TLT is not targeting human proteins, antigens, antibodys or other... they are targeting mammalian tissue and destroying the cell via O2 generation at the nucleus. Can Pharma put 2 and 2 together and maybe decide this may be worthwhile to pursue? So, by next fall you might just have an argument that supports funding of TLT sooner rather than later... or you might want to proceed with your option of DEAD TIME over the next 3-4 years. I think my 1st step would be to at least look into the feasibility of working with the vast number of veterinary oncology centers out there. So, in short, my idea is at least to explore a plan of action to eliminate as much DEAD TIME as possible.