Excessive Naproxen Usage/Dosage Can Lead to Death So why was Naproxen even accepted as a safe NSAID treatment for inflammatory conditions by the FDA ?
Maybe because at lower doses even Naproxen is safe and effective, albeit it still can cause gastrointestinal problems especially with long term use.
ATB-346 has the potential to produce similar COX inhibition as Naproxen, but without the potential GI side effects associated with NSAIDs like Naproxen, Celebrex etc.
Why CasusFortuitous continues to emphasize the adverse effects encountered with high dosages of ATB-346 of 750 mg or greater is beyond me. Why not emphasize the positive effects patients experienced at the lower dosages of 250 mg or less?
Why not emphasize the health risks of Naproxen, which has sales are in the $Billions, yet high dosages and/or prolonged usage can lead to serious side effects including death.
CasusFortuitous seems to have an agenda posting here, instilling doubt, and even going as far as implying that Antibe has an incentive to "fabricate or obfuscate" results from Phase 1 testing. He is treading on a very thin line in my opinion, and for what purpose.
I believe the only one here who is fabricating or obfuscating anything is CasusFortuitous. Why hasn't he emphasized the risks of over dosing with Naproxen? Maybe it doesn't jive with his agenda. Just my opinion.
https://www.drugs.com/naproxen.html
Before taking this medicine
Naproxen may increase your risk of heart attack or stroke, especially if you use it long term or have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are taking this medicine.
https://arthritis.about.com/od/naproxen/a/naproxen.htm
What special warnings and precautions are associated with naproxen?
Problems with stomach ulcers and stomach bleeding can occur with any NSAID, and naproxen is no exception. Typically, these problems are tied to long-term use of the drug but not always -- short-term use of naproxen or other NSAIDs can be problematic for some patients. Stomach ulcers and bleeding can occur without warning. Some people do get signs and warnings by experiencing burning stomach pain, black stools, or vomiting. Call your doctor if you are experiencing these symptoms.
Liver damage can occur in people taking NSAIDs like naproxen. Warning signs include nausea, vomiting, fatigue, appetite loss, itching, yellowing of the skin or eyes, and dark urine.
Naproxen can cause fluid retention and swelling in the body. NSAIDs like naproxen have also been linked to increased blood pressure.
NSAIDs, including naproxen, are associated with an increased risk of adverse cardiovascular events, including heart attack, stroke, and new onset or worsening of pre-existing hypertension (high blood pressure). The cardiovascular risk may be increased with duration of use of naproxen or other NSAIDs or pre-existing cardiovascular risk factors or disease.
What are the signs of overdose with naproxen?
As with any medication, there can be severe consequences of taking excessive doses of naproxen. Overdose of naproxen or other NSAIDs can cause nausea, vomiting andgastrointestinal bleeding. Other serious potential consequences of overdose include kidney and liver damage, meningitis, circulatory collapse and even death. Be sure to take naproxen only as directed.