TSXV:BTI.H - Post by User
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BearDownAZon Aug 12, 2015 12:47pm
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Post# 24011246
RE:RE:RE:RE:Scarpa LSD Study
RE:RE:RE:RE:Scarpa LSD StudyThe errors on the slides for the July 31st Scarpa/Hunter Syndrome presentation seem to have been fixed. Either that, or I still don't see the problem. Now it shows the urine GAG levels for normal mice as ~600 ug GAG/mg creatinine and ~1300 ug GAG/mg creatinine for the untreated MPS II disease mice. Very likely both of these groups (normal and "untreated MPS II disease mice) were administered a "vehicle only" or "mock treatement" to mimic the handling and treatment regimes with the exception of the injection not including the enzyme (only whatever buffer or liquid formulation the enzyme is in).
One thing I just picked up on. For the urine GAG slide, they show levels for MPS II disease mice treated with I2S alone, I2S-MTf and I2S-MTfp, but for the liver GAG slide as well as the three brain region slide (corpus callosum, cerebral cortex and thalamus), the group of MPS II disease mice treated with I2S alone (no MTf or MTfp carrier) is not shown.
I previously wrote that it would have been nice for them to include this additional control group and mistakenly thought that they didn't have this group. However, the fact that they show this group for urine GAG levels leads me to believe they do have this data. Why not show it? Why not highlight how much more effective I2S-MTf and I2S-MTfp are relative to I2S alone in THE BRAIN. Wasn't that the point of the study!
BDAZ