RE:How many patients required...Gimebrake- thanks for that article it answers some important questions- but leaves me with others.
"Generally, the smaller the clinically relevant differences in efficacy between treatments, the more patients are required, to provide sufficient statistical power and meaningful clinical results."
Okay that is clear. It expains why we can go in with so few trial numbers.
Next question: what are randomized patients?
They say in a clinical study the patients must be have similar pathology. If patients must be similar how can they be randomized.